Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150446..150951 Replicon chromosome
Accession NZ_CP008865
Organism Pseudomonas aeruginosa strain S86968

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HW02_RS00680 Protein ID WP_059319186.1
Coordinates 150446..150727 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HW02_RS00685 Protein ID WP_003112628.1
Coordinates 150724..150951 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW02_RS00655 145697..147046 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HW02_RS00660 147095..147781 + 687 WP_003083762.1 FadR family transcriptional regulator -
HW02_RS00665 147882..148616 + 735 WP_003117208.1 GntR family transcriptional regulator -
HW02_RS00670 148820..149206 + 387 WP_014602345.1 aegerolysin family protein -
HW02_RS00675 149238..150146 - 909 WP_016561475.1 LysR family transcriptional regulator -
HW02_RS00680 150446..150727 - 282 WP_059319186.1 type II toxin-antitoxin system toxin ParE Toxin
HW02_RS00685 150724..150951 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HW02_RS00690 151127..151747 - 621 WP_003101226.1 hypothetical protein -
HW02_RS00695 151848..152348 + 501 WP_003112629.1 LEA type 2 family protein -
HW02_RS00700 152421..152762 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HW02_RS00705 152844..154271 - 1428 WP_003083784.1 GABA permease -
HW02_RS00710 154440..155933 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10434.18 Da        Isoelectric Point: 10.3119

>T47776 WP_059319186.1 NZ_CP008865:c150727-150446 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVAITP

Download         Length: 282 bp

>T47776 NZ_CP008865:c150727-150446 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGCAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT47776 WP_003112628.1 NZ_CP008865:c150951-150724 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT47776 NZ_CP008865:c150951-150724 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References