Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143187..143692 Replicon chromosome
Accession NZ_CP008864
Organism Pseudomonas aeruginosa strain W60856

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag HV95_RS00655 Protein ID WP_003121619.1
Coordinates 143187..143468 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HV95_RS00660 Protein ID WP_003112628.1
Coordinates 143465..143692 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV95_RS00630 138438..139787 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HV95_RS00635 139836..140522 + 687 WP_003083762.1 FadR family transcriptional regulator -
HV95_RS00640 140623..141357 + 735 WP_003117208.1 GntR family transcriptional regulator -
HV95_RS00645 141561..141947 + 387 WP_014602345.1 aegerolysin family protein -
HV95_RS00650 141979..142887 - 909 WP_031690255.1 LysR family transcriptional regulator -
HV95_RS00655 143187..143468 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
HV95_RS00660 143465..143692 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HV95_RS00665 143868..144488 - 621 WP_003101226.1 hypothetical protein -
HV95_RS00670 144589..145089 + 501 WP_003112629.1 LEA type 2 family protein -
HV95_RS00675 145162..145503 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HV95_RS00680 145585..147012 - 1428 WP_003083784.1 GABA permease -
HV95_RS00685 147181..148674 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T47769 WP_003121619.1 NZ_CP008864:c143468-143187 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T47769 NZ_CP008864:c143468-143187 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT47769 WP_003112628.1 NZ_CP008864:c143692-143465 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT47769 NZ_CP008864:c143692-143465 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCTACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References