47757

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 179610..180115 Replicon chromosome
Accession NZ_CP008862
Organism Pseudomonas aeruginosa strain M1608

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HW04_RS00910 Protein ID WP_003083773.1
Coordinates 179610..179891 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag HW04_RS00915 Protein ID WP_003137009.1
Coordinates 179888..180115 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW04_RS00885 174861..176210 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
HW04_RS00890 176259..176945 + 687 WP_003083762.1 FadR family transcriptional regulator -
HW04_RS00895 177046..177780 + 735 WP_003110658.1 GntR family transcriptional regulator -
HW04_RS00900 177984..178370 + 387 WP_003083767.1 aegerolysin family protein -
HW04_RS00905 178402..179310 - 909 WP_003083769.1 LysR family transcriptional regulator -
HW04_RS00910 179610..179891 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HW04_RS00915 179888..180115 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
HW04_RS00920 180291..180914 - 624 WP_003137011.1 hypothetical protein -
HW04_RS00925 181015..181515 + 501 WP_003137013.1 LEA type 2 family protein -
HW04_RS00930 181587..181928 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HW04_RS00935 182010..183437 - 1428 WP_003137015.1 GABA permease -
HW04_RS00940 183606..185099 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T47757 WP_003083773.1 NZ_CP008862:c179891-179610 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T47757 NZ_CP008862:c179891-179610 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT47757 WP_003137009.1 NZ_CP008862:c180115-179888 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp

>AT47757 NZ_CP008862:c180115-179888 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References