Detailed information of TA system TA047752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 3659849..3660354
• Replicon: chromosome
• Accession: NZ_CP008861
• Organism: Pseudomonas aeruginosa strain H47921

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: HW05_RS16890
• Protein ID: WP_003083773.1
• Coordinates: 3660073..3660354 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: HW05_RS16885
• Protein ID: WP_003083775.1
• Coordinates: 3659849..3660076 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW05_RS16860	3654867..3656360	+	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
HW05_RS16865	3656529..3657956	+	1428	WP_003083784.1	GABA permease	-
HW05_RS16870	3658038..3658379	-	342	WP_003101229.1	alkylphosphonate utilization protein	-
HW05_RS16875	3658452..3658952	-	501	WP_057386938.1	LEA type 2 family protein	-
HW05_RS16880	3659053..3659673	+	621	WP_003101226.1	hypothetical protein	-
HW05_RS16885	3659849..3660076	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
HW05_RS16890	3660073..3660354	+	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
HW05_RS16895	3660654..3661562	+	909	WP_057386940.1	LysR family transcriptional regulator	-
HW05_RS16900	3661594..3661980	-	387	WP_003083767.1	aegerolysin family protein	-
HW05_RS16905	3662184..3662918	-	735	WP_003117208.1	GntR family transcriptional regulator	-
HW05_RS16910	3663019..3663705	-	687	WP_003083762.1	FadR family transcriptional regulator	-
HW05_RS16915	3663754..3665103	-	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T47752 WP_003083773.1 NZ_CP008861:3660073-3660354 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T47752 NZ_CP008861:3660073-3660354 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGTAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT47752 WP_003083775.1 NZ_CP008861:3659849-3660076 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT47752 NZ_CP008861:3659849-3660076 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGATGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9