Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144393..144898 Replicon chromosome
Accession NZ_CP008858
Organism Pseudomonas aeruginosa strain F63912

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HW08_RS00675 Protein ID WP_003083773.1
Coordinates 144393..144674 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HW08_RS00680 Protein ID WP_003083775.1
Coordinates 144671..144898 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW08_RS00650 139644..140993 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HW08_RS00655 141042..141728 + 687 WP_003083762.1 FadR family transcriptional regulator -
HW08_RS00660 141829..142563 + 735 WP_003117208.1 GntR family transcriptional regulator -
HW08_RS00665 142767..143153 + 387 WP_014602345.1 aegerolysin family protein -
HW08_RS00670 143185..144093 - 909 WP_016561475.1 LysR family transcriptional regulator -
HW08_RS00675 144393..144674 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HW08_RS00680 144671..144898 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HW08_RS00685 145075..145695 - 621 WP_009314940.1 hypothetical protein -
HW08_RS00690 145796..146296 + 501 WP_003112629.1 LEA type 2 family protein -
HW08_RS00695 146369..146710 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HW08_RS00700 146792..148219 - 1428 WP_003083784.1 GABA permease -
HW08_RS00705 148388..149881 - 1494 WP_016561476.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T47731 WP_003083773.1 NZ_CP008858:c144674-144393 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T47731 NZ_CP008858:c144674-144393 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT47731 WP_003083775.1 NZ_CP008858:c144898-144671 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT47731 NZ_CP008858:c144898-144671 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6XRW


Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References