Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2772055..2772628 Replicon chromosome
Accession NZ_CP008857
Organism Pseudomonas aeruginosa strain F30658

Toxin (Protein)


Gene name relE Uniprot ID W5IUR0
Locus tag HW09_RS12710 Protein ID WP_009618209.1
Coordinates 2772055..2772342 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5ISI7
Locus tag HW09_RS12715 Protein ID WP_009618210.1
Coordinates 2772329..2772628 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW09_RS12685 2767697..2769712 - 2016 WP_013982117.1 DNA topoisomerase III -
HW09_RS12690 2770007..2770390 - 384 WP_004362284.1 single-stranded DNA-binding protein -
HW09_RS12695 2770387..2770935 - 549 WP_031641644.1 DUF3158 family protein -
HW09_RS12700 2770932..2771711 - 780 WP_013982115.1 TIGR03761 family integrating conjugative element protein -
HW09_RS12705 2771835..2772026 - 192 WP_011805449.1 hypothetical protein -
HW09_RS12710 2772055..2772342 - 288 WP_009618209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW09_RS12715 2772329..2772628 - 300 WP_009618210.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HW09_RS12720 2772756..2773949 - 1194 WP_013982114.1 hypothetical protein -
HW09_RS12725 2773952..2774512 - 561 WP_013982113.1 DUF2857 domain-containing protein -
HW09_RS12730 2774530..2776188 - 1659 WP_013982112.1 ParB family protein -
HW09_RS12735 2776181..2776417 - 237 WP_013982111.1 type II toxin-antitoxin system HicA family toxin -
HW09_RS12740 2776401..2777267 - 867 WP_013982110.1 ParA family protein -
HW09_RS12745 2777308..2777526 - 219 WP_023084999.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2697739..2810053 112314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10854.46 Da        Isoelectric Point: 8.4628

>T47726 WP_009618209.1 NZ_CP008857:c2772342-2772055 [Pseudomonas aeruginosa]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Download         Length: 288 bp

>T47726 NZ_CP008857:c2772342-2772055 [Pseudomonas aeruginosa]
GTGCGCGTACTTGAGTGGCGGGAAGCTGCCCGCGCCGACCTGCTGGCGATTGTTGACTACATCTCGGACGACAACCCCGA
TGCCGCGCAGCGGTTGAAGGACGACATCGAGGCCAAGGCCGCGAAGCTGCCGGAGCGCCCGAAGCTCTACCGGCCTGGCC
GCGTGGCCGGCACGCGGGAGATGGTCGTGCGTGCGAACTACGTGGTGGTCTACATGGAGGACACCCGCGCGGTGTCCATC
CTGCGCGTGTTGCACGCCGCGCAGCAGTGGCCGCCGGCACGGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10816.46 Da        Isoelectric Point: 8.6579

>AT47726 WP_009618210.1 NZ_CP008857:c2772628-2772329 [Pseudomonas aeruginosa]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Download         Length: 300 bp

>AT47726 NZ_CP008857:c2772628-2772329 [Pseudomonas aeruginosa]
ATGGCCGCACAGACTTCGATGCTGCACATCCGCGTGGACGATAAGCTCAAGGCCGATGCAGCCGAGAAACTCGCCGGGGT
CGGCCTCACCGTTTCGGACGCCGTGCGCATCCTGCTGACCCGTGTGGTCAAGGAAGGCGCACTGCCGGCTGGCCTCACGG
CCGACCCGGAGGCCTACGATGCCTGGTTCCGGGCGAAGGTCCAGGAGGCGCTGGCCGACACACGGCCGCCGGTGCCGCAC
CAGCAGGTCATGGATGAGGCGCAGGCCCTGATCGACAGGAAGCGGCGTGCGCGTACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9QF16

Antitoxin

Source ID Structure
AlphaFold DB A0A5R9QE11

References