Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5276233..5276780 Replicon chromosome
Accession NZ_CP008856
Organism Pseudomonas aeruginosa strain F23197

Toxin (Protein)


Gene name relE Uniprot ID A0A6A9K6G2
Locus tag HW10_RS24775 Protein ID WP_023102603.1
Coordinates 5276505..5276780 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6A9LA76
Locus tag HW10_RS24770 Protein ID WP_023102602.1
Coordinates 5276233..5276505 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW10_RS24750 5272900..5273931 + 1032 WP_073700136.1 hypothetical protein -
HW10_RS24755 5273942..5274607 + 666 WP_075116957.1 DUF3218 family protein -
HW10_RS30920 5275029..5275364 + 336 WP_172403162.1 hypothetical protein -
HW10_RS24765 5275421..5275981 - 561 WP_023102601.1 recombinase family protein -
HW10_RS24770 5276233..5276505 + 273 WP_023102602.1 ribbon-helix-helix domain-containing protein Antitoxin
HW10_RS24775 5276505..5276780 + 276 WP_023102603.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW10_RS24780 5277021..5277656 - 636 WP_023102604.1 hypothetical protein -
HW10_RS24785 5277656..5279527 - 1872 WP_059303259.1 hypothetical protein -
HW10_RS24790 5279499..5281616 - 2118 WP_023102606.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5221858..5338071 116213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10689.27 Da        Isoelectric Point: 9.9307

>T47719 WP_023102603.1 NZ_CP008856:5276505-5276780 [Pseudomonas aeruginosa]
MELKWTNKGLSDLTRLYEFLAAVNRSAAARTVQQLTSAPTKLLANPRIGERLEEFDPRDVRRILVGHYEMRYEIAGSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T47719 NZ_CP008856:5276505-5276780 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAACAAGGGGCTGTCCGATCTGACTCGACTATATGAGTTCCTGGCGGCTGTGAACCGTTCCGC
TGCGGCACGTACCGTGCAACAGCTAACGAGCGCACCGACTAAGCTGCTGGCCAACCCGCGCATCGGTGAGCGCCTGGAAG
AGTTCGATCCGCGTGACGTGCGGCGGATTCTGGTCGGGCATTACGAGATGCGCTACGAAATTGCGGGCTCTACCATCTAT
CTGCTGCGTCTGTGGCACACCCGTGAAGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10087.34 Da        Isoelectric Point: 4.6413

>AT47719 WP_023102602.1 NZ_CP008856:5276233-5276505 [Pseudomonas aeruginosa]
MPANAKTRSVTAHVPIELAERVDDIAERLERSKNWIVKQALTAWLDQEDERSRLTREALVDVDAGCVIDHQAVQAWADSL
STDTPLPVPR

Download         Length: 273 bp

>AT47719 NZ_CP008856:5276233-5276505 [Pseudomonas aeruginosa]
ATGCCCGCTAACGCCAAAACCAGATCTGTCACCGCCCATGTCCCCATTGAGCTGGCCGAACGTGTCGATGACATCGCAGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAGGCTCTTACAGCCTGGCTCGACCAGGAAGACGAGCGTAGCCGCC
TGACCCGCGAGGCTCTGGTGGATGTGGATGCCGGCTGCGTGATTGACCATCAGGCAGTCCAGGCCTGGGCCGATAGCCTT
AGTACCGACACTCCGCTGCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A9K6G2

Antitoxin

Source ID Structure
AlphaFold DB A0A6A9LA76

References