Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 145632..146137 Replicon chromosome
Accession NZ_CP008856
Organism Pseudomonas aeruginosa strain F23197

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag HW10_RS00685 Protein ID WP_003121619.1
Coordinates 145632..145913 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag HW10_RS00690 Protein ID WP_003112628.1
Coordinates 145910..146137 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW10_RS00660 140883..142232 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
HW10_RS00665 142281..142967 + 687 WP_003083762.1 FadR family transcriptional regulator -
HW10_RS00670 143068..143802 + 735 WP_004346926.1 GntR family transcriptional regulator -
HW10_RS00675 144006..144392 + 387 WP_180705133.1 aegerolysin family protein -
HW10_RS00680 144424..145332 - 909 WP_016561475.1 LysR family transcriptional regulator -
HW10_RS00685 145632..145913 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
HW10_RS00690 145910..146137 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
HW10_RS00695 146313..146933 - 621 WP_023088714.1 hypothetical protein -
HW10_RS00700 147034..147534 + 501 WP_003101228.1 LEA type 2 family protein -
HW10_RS00705 147607..147948 + 342 WP_033937008.1 alkylphosphonate utilization protein -
HW10_RS00710 148030..149457 - 1428 WP_059303232.1 GABA permease -
HW10_RS00715 149626..151119 - 1494 WP_033937007.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T47714 WP_003121619.1 NZ_CP008856:c145913-145632 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T47714 NZ_CP008856:c145913-145632 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT47714 WP_003112628.1 NZ_CP008856:c146137-145910 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT47714 NZ_CP008856:c146137-145910 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References