Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1782637..1783213 Replicon chromosome
Accession NZ_CP008841
Organism Klebsiella michiganensis strain M1

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag HR38_RS08365 Protein ID WP_038424021.1
Coordinates 1782637..1782924 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0H3H591
Locus tag HR38_RS08370 Protein ID WP_014227757.1
Coordinates 1782911..1783213 (+) Length 101 a.a.

Genomic Context

HR38_RS08355HR38_RS08360HR38_RS08365HR38_RS08370HR38_RS08335HR38_RS08340HR38_RS08345HR38_RS08350HR38_RS08375HR38_RS08380HR38_RS08385
Location: 1781042..1781950 (909 bp)
Type: Others
Protein ID: WP_014837311.1
Location: 1781944..1782387 (444 bp)
Type: Others
Protein ID: WP_014837312.1
Location: 1782637..1782924 (288 bp)
Type: Toxin
Protein ID: WP_038424021.1
Location: 1782911..1783213 (303 bp)
Type: Antitoxin
Protein ID: WP_014227757.1
Location: 1777979..1778497 (519 bp)
Type: Others
Protein ID: WP_004098240.1
Location: 1778494..1779294 (801 bp)
Type: Others
Protein ID: WP_014837308.1
Location: 1779440..1780024 (585 bp)
Type: Others
Protein ID: WP_004098242.1
Location: 1780172..1780954 (783 bp)
Type: Others
Protein ID: WP_014837310.1
Location: 1783334..1784677 (1344 bp)
Type: Others
Protein ID: WP_032719935.1
Location: 1784674..1785585 (912 bp)
Type: Others
Protein ID: WP_032719936.1
Location: 1786038..1786373 (336 bp)
Type: Others
Protein ID: WP_014227760.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HR38_RS083351777979..1778497-519WP_004098240.1hypothetical protein-
HR38_RS083401778494..1779294-801WP_014837308.1winged helix-turn-helix domain-containing protein-
HR38_RS083451779440..1780024-585WP_004098242.1TetR/AcrR family transcriptional regulator-
HR38_RS083501780172..1780954-783WP_014837310.1NAD(P)H-dependent oxidoreductase-
HR38_RS083551781042..1781950+909WP_014837311.1LysR family transcriptional regulator-
HR38_RS083601781944..1782387+444WP_014837312.1FosA family fosfomycin resistance glutathione transferase-
HR38_RS083651782637..1782924+288WP_038424021.1BrnT family toxinToxin
HR38_RS083701782911..1783213+303WP_014227757.1BrnA antitoxin family proteinAntitoxin
HR38_RS083751783334..1784677-1344WP_032719935.1APC family permease-
HR38_RS083801784674..1785585-912WP_032719936.1acetamidase/formamidase family protein-
HR38_RS083851786038..1786373-336WP_014227760.1endoribonuclease SymE-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11253.72 Da        Isoelectric Point: 8.5899

>T47692 WP_038424021.1 NZ_CP008841:1782637-1782924 [Klebsiella michiganensis]
MPMEFEWDANKARSNLRKHGIRFEEAVLVFDDPRHLSRQDRYENGEYRWQTLGLVHGIIVIMVAHSVRFESGTEVIRIIS
ARKADSKERNRYEHG

Download         Length: 288 bp

>T47692 NZ_CP008841:1782637-1782924 [Klebsiella michiganensis]
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAAGAAGTAATCTAAGAAAACATGGAATCCGGTTTGAGGAAGCGGT
GCTCGTCTTTGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTCTCGGCC
TCGTTCATGGGATCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11607.18 Da        Isoelectric Point: 9.4429

>AT47692 WP_014227757.1 NZ_CP008841:1782911-1783213 [Klebsiella michiganensis]
MNMVKHKRDNPDTLTAKRDDELKALANKTDDEIDYSDIPATDDAQWSDAVRGKFYRPLKTQASVRIDADIMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp

>AT47692 NZ_CP008841:1782911-1783213 [Klebsiella michiganensis]
ATGAACATGGTTAAACATAAACGTGACAATCCGGATACGCTTACGGCTAAGCGAGACGATGAGCTTAAAGCGCTGGCCAA
CAAAACGGATGATGAAATCGATTATAGCGATATTCCCGCCACAGACGACGCACAGTGGTCAGATGCCGTACGCGGTAAAT
TTTACCGACCGCTAAAAACTCAGGCTTCTGTCCGTATTGATGCCGATATTATGGAGTGGCTTAAACGTCCCGGGAAAGGT
TATCAAACGCGACTGAATGCGATCTTAAGAGAAGCGATGATTCGCGATCTTAACAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0H3H591

References