Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 989213..989760 Replicon chromosome
Accession NZ_CP008841
Organism Klebsiella michiganensis strain M1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3H5T3
Locus tag HR38_RS04670 Protein ID WP_014227299.1
Coordinates 989452..989760 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3H0P7
Locus tag HR38_RS04665 Protein ID WP_014227298.1
Coordinates 989213..989449 (+) Length 79 a.a.

Genomic Context

HR38_RS04650HR38_RS04655HR38_RS04660HR38_RS04665HR38_RS04670HR38_RS04675HR38_RS04690HR38_RS04700HR38_RS04680HR38_RS04685HR38_RS04695
Location: 985420..986586 (1167 bp)
Type: Others
Protein ID: WP_014839828.1
Location: 986747..987649 (903 bp)
Type: Others
Protein ID: WP_038423879.1
Location: 987674..989107 (1434 bp)
Type: Others
Protein ID: WP_038423880.1
Location: 989213..989449 (237 bp)
Type: Antitoxin
Protein ID: WP_014227298.1
Location: 989452..989760 (309 bp)
Type: Toxin
Protein ID: WP_014227299.1
Location: 989911..990813 (903 bp)
Type: Others
Protein ID: WP_009654083.1
Location: 992249..992542 (294 bp)
Type: Others
Protein ID: WP_014227302.1
Location: 993802..994113 (312 bp)
Type: Others
Protein ID: WP_038423882.1
Location: 990817..991074 (258 bp)
Type: Others
Protein ID: WP_032718834.1
Location: 991074..992039 (966 bp)
Type: Others
Protein ID: WP_038423881.1
Location: 992566..993507 (942 bp)
Type: Others
Protein ID: WP_014227303.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HR38_RS04650985420..986586+1167WP_014839828.1multidrug effflux MFS transporter-
HR38_RS04655986747..987649+903WP_038423879.1N-acetylmuramic acid 6-phosphate etherase-
HR38_RS04660987674..989107+1434WP_038423880.1PTS N-acetylmuramic acid transporter subunit IIBC-
HR38_RS04665989213..989449+237WP_014227298.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
HR38_RS04670989452..989760+309WP_014227299.1CcdB family proteinToxin
HR38_RS04675989911..990813+903WP_009654083.1DMT family transporter-
HR38_RS04680990817..991074-258WP_032718834.1hypothetical protein-
HR38_RS04685991074..992039-966WP_038423881.1Rpn family recombination-promoting nuclease/putative transposase-
HR38_RS04690992249..992542+294WP_014227302.1hypothetical protein-
HR38_RS04695992566..993507-942WP_014227303.1LacI family transcriptional regulator-
HR38_RS04700993802..994113+312WP_038423882.1PTS sugar transporter subunit IIB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11725.57 Da        Isoelectric Point: 7.2729

>T47689 WP_014227299.1 NZ_CP008841:989452-989760 [Klebsiella michiganensis]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

>T47689 NZ_CP008841:989452-989760 [Klebsiella michiganensis]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGTATCCCACATCGTGTTCTGGGTGAAGAA
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8783.92 Da        Isoelectric Point: 5.7928

>AT47689 WP_014227298.1 NZ_CP008841:989213-989449 [Klebsiella michiganensis]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT47689 NZ_CP008841:989213-989449 [Klebsiella michiganensis]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCAGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3H5T3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3H0P7

References