Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1829195..1829850 Replicon chromosome
Accession NZ_CP008834
Organism Burkholderia pseudomallei strain BGR

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag DP60_RS08365 Protein ID WP_006027262.1
Coordinates 1829554..1829850 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag DP60_RS08360 Protein ID WP_004202809.1
Coordinates 1829195..1829551 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP60_RS08340 1824330..1825343 - 1014 WP_038729266.1 phage major capsid protein, P2 family -
DP60_RS08345 1825377..1826186 - 810 WP_004552664.1 GPO family capsid scaffolding protein -
DP60_RS08350 1826330..1828099 + 1770 WP_004531046.1 terminase ATPase subunit family protein -
DP60_RS08355 1828096..1829151 + 1056 WP_004531045.1 phage portal protein -
DP60_RS08360 1829195..1829551 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
DP60_RS08365 1829554..1829850 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DP60_RS33090 1830518..1831774 + 1257 WP_004552667.1 AAA family ATPase -
DP60_RS08370 1831819..1832394 + 576 WP_198014201.1 DUF4276 family protein -
DP60_RS08375 1833166..1833492 + 327 WP_004552669.1 hypothetical protein -
DP60_RS08380 1833485..1833898 + 414 WP_004527843.1 phage tail protein I -
DP60_RS08385 1833796..1834398 + 603 WP_076880366.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1773455..1835853 62398


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T47684 WP_006027262.1 NZ_CP008834:c1829850-1829554 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T47684 NZ_CP008834:c1829850-1829554 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT47684 WP_004202809.1 NZ_CP008834:c1829551-1829195 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT47684 NZ_CP008834:c1829551-1829195 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References