Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3894337..3894994 Replicon chromosome
Accession NZ_CP008823
Organism UNVERIFIED_ORG: Enterobacter cloacae ECNIH2

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag ECNIH2_RS18670 Protein ID WP_017382887.1
Coordinates 3894337..3894747 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag ECNIH2_RS18675 Protein ID WP_003863437.1
Coordinates 3894728..3894994 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECNIH2_RS18650 (ECNIH2_18770) 3890335..3892068 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
ECNIH2_RS18655 (ECNIH2_18775) 3892074..3892787 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECNIH2_RS18660 (ECNIH2_18780) 3892816..3893712 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
ECNIH2_RS18665 (ECNIH2_18785) 3893814..3894335 + 522 WP_015571793.1 flavodoxin FldB -
ECNIH2_RS18670 (ECNIH2_18790) 3894337..3894747 - 411 WP_017382887.1 protein YgfX Toxin
ECNIH2_RS18675 (ECNIH2_18795) 3894728..3894994 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
ECNIH2_RS18680 (ECNIH2_18800) 3895289..3896269 + 981 WP_032619082.1 tRNA-modifying protein YgfZ -
ECNIH2_RS18685 (ECNIH2_18805) 3896381..3897040 - 660 WP_003863433.1 hemolysin III family protein -
ECNIH2_RS18690 (ECNIH2_18810) 3897307..3898038 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
ECNIH2_RS18695 (ECNIH2_18815) 3898155..3899588 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T47639 WP_017382887.1 NZ_CP008823:c3894747-3894337 [Enterobacter cloacae ECNIH2]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T47639 NZ_CP008823:c3894747-3894337 [Enterobacter cloacae ECNIH2]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT47639 WP_003863437.1 NZ_CP008823:c3894994-3894728 [Enterobacter cloacae ECNIH2]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT47639 NZ_CP008823:c3894994-3894728 [Enterobacter cloacae ECNIH2]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References