Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 201168..201887 | Replicon | chromosome |
| Accession | NZ_CP008823 | ||
| Organism | UNVERIFIED_ORG: Enterobacter cloacae ECNIH2 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A144XIR2 |
| Locus tag | ECNIH2_RS00985 | Protein ID | WP_023305176.1 |
| Coordinates | 201168..201488 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | ECNIH2_RS00990 | Protein ID | WP_032620726.1 |
| Coordinates | 201522..201887 (-) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECNIH2_RS00945 (ECNIH2_00950) | 196442..196885 | + | 444 | WP_017383639.1 | GNAT family N-acetyltransferase | - |
| ECNIH2_RS00950 (ECNIH2_00955) | 196918..197505 | - | 588 | WP_023295690.1 | hypothetical protein | - |
| ECNIH2_RS00955 (ECNIH2_00960) | 197502..197867 | - | 366 | WP_023302859.1 | DUF2778 domain-containing protein | - |
| ECNIH2_RS00960 (ECNIH2_00965) | 197877..198362 | - | 486 | WP_017383637.1 | type VI secretion system tube protein TssD | - |
| ECNIH2_RS00965 (ECNIH2_00970) | 198626..199654 | - | 1029 | WP_071842900.1 | RhuM family protein | - |
| ECNIH2_RS00970 (ECNIH2_00975) | 199713..200054 | - | 342 | WP_032620730.1 | SymE family type I addiction module toxin | - |
| ECNIH2_RS00975 (ECNIH2_00980) | 200191..200382 | + | 192 | WP_032620729.1 | toxin-antitoxin system HicB family antitoxin | - |
| ECNIH2_RS00980 (ECNIH2_00985) | 200384..200965 | - | 582 | WP_017383635.1 | hypothetical protein | - |
| ECNIH2_RS00985 (ECNIH2_00990) | 201168..201488 | - | 321 | WP_023305176.1 | TA system toxin CbtA family protein | Toxin |
| ECNIH2_RS00990 (ECNIH2_00995) | 201522..201887 | - | 366 | WP_032620726.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| ECNIH2_RS00995 | 201919..202140 | - | 222 | WP_032620724.1 | DUF987 domain-containing protein | - |
| ECNIH2_RS01000 (ECNIH2_01005) | 202149..202619 | - | 471 | WP_032620722.1 | DNA repair protein RadC | - |
| ECNIH2_RS01005 (ECNIH2_01010) | 202689..203510 | - | 822 | WP_032620720.1 | DUF932 domain-containing protein | - |
| ECNIH2_RS26845 | 203953..204144 | - | 192 | WP_023305181.1 | hypothetical protein | - |
| ECNIH2_RS26720 (ECNIH2_01015) | 204203..205042 | - | 840 | WP_050595703.1 | hypothetical protein | - |
| ECNIH2_RS01015 (ECNIH2_01020) | 205155..205589 | - | 435 | WP_044488933.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 194000..227130 | 33130 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12190.77 Da Isoelectric Point: 5.9559
>T47625 WP_023305176.1 NZ_CP008823:c201488-201168 [Enterobacter cloacae ECNIH2]
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS
MHISTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS
Download Length: 321 bp
>T47625 NZ_CP008823:c201488-201168 [Enterobacter cloacae ECNIH2]
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A
ATGCATATTTCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTGTCTCCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCTGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTGGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCTTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A
Antitoxin
Download Length: 122 a.a. Molecular weight: 13574.29 Da Isoelectric Point: 6.4673
>AT47625 WP_032620726.1 NZ_CP008823:c201887-201522 [Enterobacter cloacae ECNIH2]
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR
MQSTTISGTSAENTSCLQWELKRNITPCFGARLVQESNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR
Download Length: 366 bp
>AT47625 NZ_CP008823:c201887-201522 [Enterobacter cloacae ECNIH2]
ATGCAGTCGACCACCATATCCGGCACATCGGCGGAGAACACATCCTGCCTTCAGTGGGAATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAAGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA
ATGCAGTCGACCACCATATCCGGCACATCGGCGGAGAACACATCCTGCCTTCAGTGGGAATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAAGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|