Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 37854..38388 Replicon plasmid 2
Accession NZ_CP008814
Organism Enterococcus faecalis ATCC 29212

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag DR75_RS00225 Protein ID WP_002360769.1
Coordinates 37854..38129 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag DR75_RS00230 Protein ID WP_002369771.1
Coordinates 38122..38388 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR75_RS00200 33042..33770 - 729 WP_002383622.1 hypothetical protein -
DR75_RS00205 34419..35678 - 1260 WP_002360763.1 PcfJ domain-containing protein -
DR75_RS00210 35678..36457 - 780 WP_002383621.1 hypothetical protein -
DR75_RS00215 36689..36835 - 147 WP_002414800.1 DpnD/PcfM family protein -
DR75_RS00220 36864..37049 - 186 WP_002368099.1 hypothetical protein -
DR75_RS00225 37854..38129 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
DR75_RS00230 38122..38388 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DR75_RS00235 38499..39083 - 585 WP_002383617.1 thermonuclease family protein -
DR75_RS00240 39107..39523 - 417 WP_002414801.1 single-stranded DNA-binding protein -
DR75_RS00245 39599..39847 - 249 WP_002360773.1 DUF3850 domain-containing protein -
DR75_RS00250 39860..40360 - 501 WP_002360775.1 DnaJ domain-containing protein -
DR75_RS00255 40393..40659 - 267 WP_002360776.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..41610 41610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T47588 WP_002360769.1 NZ_CP008814:c38129-37854 [Enterococcus faecalis ATCC 29212]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T47588 NZ_CP008814:c38129-37854 [Enterococcus faecalis ATCC 29212]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAACAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAACTATTTCGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT47588 WP_002369771.1 NZ_CP008814:c38388-38122 [Enterococcus faecalis ATCC 29212]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT47588 NZ_CP008814:c38388-38122 [Enterococcus faecalis ATCC 29212]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References