Detailed information of TA system TA047581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 14132..15047
• Replicon: plasmid pCFV97608-2
• Accession: NZ_CP008812
• Organism: Campylobacter fetus subsp. venerealis 97/608

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: A0A974RKV0
• Locus tag: CFV97608_RS10150
• Protein ID: WP_024305403.1
• Coordinates: 14361..15047 (+)
• Length: 229 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: A0A974MUU2
• Locus tag: CFV97608_RS10145
• Protein ID: WP_002850985.1
• Coordinates: 14132..14368 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFV97608_RS10130	10013..11461	+	1449	WP_080723873.1	toprim domain-containing protein	-
CFV97608_RS10135	11471..13312	+	1842	WP_002850983.1	type IV secretory system conjugative DNA transfer family protein	-
CFV97608_RS10140	13309..14015	+	707	Protein_15	conjugal transfer protein TraL	-
CFV97608_RS10145	14132..14368	+	237	WP_002850985.1	hypothetical protein	Antitoxin
CFV97608_RS10150	14361..15047	+	687	WP_024305403.1	Fic family protein	Toxin
CFV97608_RS10790	15108..15344	+	237	WP_160172079.1	hypothetical protein	-
CFV97608_RS10155	15328..16428	-	1101	WP_010404252.1	transposase	-
CFV97608_RS10160	16406..16861	-	456	WP_010404250.1	IS200/IS605 family transposase	-
CFV97608_RS10165	16965..17255	+	291	WP_051945896.1	S26 family signal peptidase	-
CFV97608_RS10170	17252..17623	+	372	WP_002850989.1	hypothetical protein	-
CFV97608_RS10175	17734..18420	+	687	WP_002850991.1	AAA family ATPase	-
CFV97608_RS10180	18424..18633	+	210	WP_002850993.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..27124	27124
	-	flank	IS/Tn	-	-	16406..16861	455

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (60-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 229 a.a.
• Molecular weight: 25978.99 Da
• Isoelectric Point: 10.0098

>T47581 WP_024305403.1 NZ_CP008812:14361-15047 [Campylobacter fetus subsp. venerealis 97/608]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFKDVYTWA
GKDRMEVGLHGNFGKYAPNGTITNFVPGKDLNATAQQIFTWLKEDNYLTNSKDLNDFAKNLAEFARNLNALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLIPKDKMIMASVEASQLKLGKLEAIIKTNLKSFKQNLEKENTLGLSLC

Nucleotide

• Length: 687 bp

>T47581 NZ_CP008812:14361-15047 [Campylobacter fetus subsp. venerealis 97/608]
ATGATTGATAAAGTTTTGAAATTTTTAGATGATGGTATTCCTAAAAATGATTTTGACAGACAACTTTTAGCTTCTAATTT
AGTAGGCGCAACAAATTTAATAGAGTTAAATAAACGAGAAAGAGAAATTACATTAAAAAAACAATTAAAACTACAACTTA
ATCCAATTAAAGGCAATTTTGACTACCAACATTTAAAAGATATACATAAAGCACTTTTTAAAGATGTTTATACTTGGGCT
GGAAAAGATAGAATGGAAGTAGGTTTGCATGGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCC
TGGAAAAGATTTAAATGCAACCGCTCAACAAATTTTTACTTGGCTTAAAGAAGACAATTACTTAACAAATTCAAAAGATC
TTAACGATTTTGCAAAGAACTTAGCCGAATTTGCTAGAAACCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGA
ACTCAAAGAATATTTTTAAATGAATTGGCTAAAAATGCAGGTTATAAACTTGATTTAAATTTAATACCAAAAGATAAAAT
GATAATGGCATCTGTAGAAGCTTCACAATTGAAATTAGGAAAACTTGAAGCCATAATAAAAACAAATCTAAAAAGCTTTA
AGCAAAATTTAGAAAAAGAAAATACATTAGGCTTATCCCTATGTTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9006.20 Da
• Isoelectric Point: 4.3316

>AT47581 WP_002850985.1 NZ_CP008812:14132-14368 [Campylobacter fetus subsp. venerealis 97/608]
MTYPEVHSLEESLAILKKYKDDLTKEQYDGIKSIICGHAIEDMFANERDIIDMIKIAKNEANADEIIAEYKKEWGVND

Nucleotide

• Length: 237 bp

>AT47581 NZ_CP008812:14132-14368 [Campylobacter fetus subsp. venerealis 97/608]
ATGACATATCCAGAAGTACATAGCCTAGAAGAGAGTTTAGCAATACTTAAAAAATACAAAGATGATTTAACTAAAGAGCA
ATACGATGGAATTAAATCTATAATTTGCGGACACGCTATTGAAGATATGTTTGCAAATGAAAGAGACATTATTGATATGA
TAAAAATTGCAAAAAATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAAAGAGTGGGGAGTAAATGATTGA