Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1395913..1396708 Replicon chromosome
Accession NZ_CP008805
Organism Escherichia coli O157:H7 str. SS17

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag SS17_RS06840 Protein ID WP_000854914.1
Coordinates 1396334..1396708 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag SS17_RS06835 Protein ID WP_001280954.1
Coordinates 1395913..1396287 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SS17_RS06795 1391268..1392173 + 906 WP_000203541.1 chemotaxis protein -
SS17_RS06800 1392170..1393240 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
SS17_RS06810 1393580..1394398 + 819 WP_001234682.1 DUF945 domain-containing protein -
SS17_RS06815 1394489..1394974 + 486 WP_000214398.1 antirestriction protein -
SS17_RS06820 1394990..1395466 + 477 WP_001186738.1 RadC family protein -
SS17_RS06825 1395529..1395750 + 222 WP_001220314.1 DUF987 domain-containing protein -
SS17_RS06835 1395913..1396287 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
SS17_RS06840 1396334..1396708 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
SS17_RS06845 1396705..1397196 + 492 WP_000976853.1 hypothetical protein -
SS17_RS06850 1397208..1397405 + 198 WP_000839282.1 DUF957 domain-containing protein -
SS17_RS06855 1397490..1398332 + 843 WP_001280481.1 DUF4942 domain-containing protein -
SS17_RS06865 1398801..1399739 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
SS17_RS06870 1399794..1400531 + 738 WP_000283664.1 zinc-binding phosphatase -
SS17_RS06875 1400555..1401109 + 555 WP_001001917.1 molecular chaperone YcdY -
SS17_RS06880 1401211..1401702 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T47545 WP_000854914.1 NZ_CP008805:1396334-1396708 [Escherichia coli O157:H7 str. SS17]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T47545 NZ_CP008805:1396334-1396708 [Escherichia coli O157:H7 str. SS17]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT47545 WP_001280954.1 NZ_CP008805:1395913-1396287 [Escherichia coli O157:H7 str. SS17]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT47545 NZ_CP008805:1395913-1396287 [Escherichia coli O157:H7 str. SS17]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References