Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1139409..1140007 Replicon chromosome
Accession NZ_CP008802
Organism Actinotignum schaalii strain CCUG 27420

Toxin (Protein)


Gene name PumA Uniprot ID A0A068NMH5
Locus tag FB03_RS04870 Protein ID WP_026428436.1
Coordinates 1139409..1139717 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FB03_RS04875 Protein ID WP_026428437.1
Coordinates 1139714..1140007 (+) Length 98 a.a.

Genomic Context

FB03_RS04855FB03_RS09795FB03_RS04870FB03_RS04875FB03_RS04860FB03_RS09205FB03_RS04885
Location: 1134425..1135975 (1551 bp)
Type: Others
Protein ID: WP_026428435.1
Location: 1137511..1139229 (1719 bp)
Type: Others
Protein ID: WP_051278175.1
Location: 1139409..1139717 (309 bp)
Type: Toxin
Protein ID: WP_026428436.1
Location: 1139714..1140007 (294 bp)
Type: Antitoxin
Protein ID: WP_026428437.1
Location: 1135988..1136707 (720 bp)
Type: Others
Protein ID: WP_051278173.1
Location: 1140347..1141291 (945 bp)
Type: Others
Protein ID: WP_026428438.1
Location: 1141590..1144826 (3237 bp)
Type: Others
Protein ID: WP_038505523.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FB03_RS048551134425..1135975+1551WP_026428435.1hypothetical protein-
FB03_RS048601135988..1136707-720WP_051278173.1hypothetical protein-
FB03_RS097951137511..1139229+1719WP_051278175.1hypothetical protein-
FB03_RS048701139409..1139717+309WP_026428436.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FB03_RS048751139714..1140007+294WP_026428437.1putative addiction module antidote proteinAntitoxin
FB03_RS092051140347..1141291-945WP_026428438.1LysR family transcriptional regulator-
FB03_RS048851141590..1144826-3237WP_038505523.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-84)

Antitoxin

Uncharacterized protein HI1420

(6-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11442.15 Da        Isoelectric Point: 8.0752

>T47536 WP_026428436.1 NZ_CP008802:1139409-1139717 [Actinotignum schaalii]
MEMLSSSLFDAWLDKLKDKHAQRRILHAIARCEAHGMMLGDIKPVGGKVSEMRFHFGSGYRVYYTQLGTVTVFLLAGGDK
SSQSSDIQVAQELAKQLREEQP

Download         Length: 309 bp

>T47536 NZ_CP008802:1139409-1139717 [Actinotignum schaalii]
ATGGAGATGCTTTCCAGTAGCTTGTTTGATGCGTGGCTAGACAAGCTGAAAGACAAACACGCGCAGCGGCGTATCTTGCA
CGCAATAGCCAGATGCGAAGCTCACGGAATGATGCTAGGAGATATCAAACCTGTTGGCGGAAAAGTCAGCGAGATGAGAT
TTCATTTCGGTTCGGGCTACCGGGTGTACTACACGCAGCTAGGTACAGTAACGGTTTTCCTGTTAGCCGGCGGAGATAAA
TCCAGCCAAAGCAGCGACATTCAGGTAGCGCAAGAACTGGCAAAACAGCTCAGGGAGGAACAACCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10704.28 Da        Isoelectric Point: 8.4394

>AT47536 WP_026428437.1 NZ_CP008802:1139714-1140007 [Actinotignum schaalii]
MTKVTFSTFDASKYLDSQEAMNDYLAIALEDGDTKTVQVVLRDIARARGMSQLAKDTELNRESLYKSLSKDGNPSFATIT
KIMKALGLKITLAPQNV

Download         Length: 294 bp

>AT47536 NZ_CP008802:1139714-1140007 [Actinotignum schaalii]
ATGACCAAGGTAACTTTTTCAACTTTCGACGCAAGCAAATACCTTGATAGTCAAGAAGCAATGAATGACTACCTTGCTAT
TGCTCTCGAAGATGGCGACACAAAAACCGTGCAGGTAGTTTTGCGCGATATTGCCCGGGCTCGCGGCATGAGCCAGCTCG
CTAAAGATACTGAACTCAACCGCGAATCGCTCTATAAATCACTGTCAAAAGACGGCAATCCGTCCTTTGCTACTATCACG
AAAATCATGAAAGCCCTCGGACTGAAAATAACGCTTGCTCCCCAAAACGTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A068NMH5

Antitoxin

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Source
ID
Structure
No matching records found

References