Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 139179..139822 Replicon plasmid pKPC-727
Accession NZ_CP008791
Organism Klebsiella oxytoca KONIH1

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag KONIH1_RS31400 Protein ID WP_001044770.1
Coordinates 139406..139822 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag KONIH1_RS31395 Protein ID WP_001261282.1
Coordinates 139179..139409 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KONIH1_RS35595 134408..134710 + 303 WP_071571079.1 hypothetical protein -
KONIH1_RS31370 135142..135936 - 795 WP_004197635.1 site-specific integrase -
KONIH1_RS31375 136134..137150 - 1017 WP_017899884.1 hypothetical protein -
KONIH1_RS33770 137161..137475 - 315 WP_053389906.1 hypothetical protein -
KONIH1_RS31380 137502..137897 - 396 WP_017899885.1 hypothetical protein -
KONIH1_RS31385 138066..138371 - 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB -
KONIH1_RS31390 138373..138591 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA -
KONIH1_RS33780 138761..139222 - 462 WP_162763201.1 hypothetical protein -
KONIH1_RS31395 139179..139409 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KONIH1_RS31400 139406..139822 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
KONIH1_RS31405 139896..140132 + 237 WP_001348075.1 AAA family ATPase -
KONIH1_RS31410 140179..140883 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
KONIH1_RS33785 140933..141157 - 225 Protein_165 DUF4158 domain-containing protein -
KONIH1_RS31420 141321..141878 + 558 WP_001217881.1 recombinase family protein -
KONIH1_RS31425 142112..142666 + 555 WP_014454105.1 aminoglycoside N-acetyltransferase AAC(6')-Ib' -
KONIH1_RS31430 142736..143524 + 789 WP_001206315.1 ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1 -
KONIH1_RS33790 143584..144408 + 825 WP_000722315.1 oxacillin-hydrolyzing class D beta-lactamase OXA-9 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaKPC-2 / aac(6')-Ib / ant(3'')-Ia / blaOXA-9 - 1..205586 205586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T47466 WP_001044770.1 NZ_CP008791:139406-139822 [Klebsiella oxytoca KONIH1]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T47466 NZ_CP008791:139406-139822 [Klebsiella oxytoca KONIH1]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT47466 WP_001261282.1 NZ_CP008791:139179-139409 [Klebsiella oxytoca KONIH1]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT47466 NZ_CP008791:139179-139409 [Klebsiella oxytoca KONIH1]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References