Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 138066..138591 | Replicon | plasmid pKPC-727 |
| Accession | NZ_CP008791 | ||
| Organism | Klebsiella oxytoca KONIH1 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | D4HQE7 |
| Locus tag | KONIH1_RS31385 | Protein ID | WP_013023785.1 |
| Coordinates | 138066..138371 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | W8V2V6 |
| Locus tag | KONIH1_RS31390 | Protein ID | WP_001568025.1 |
| Coordinates | 138373..138591 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KONIH1_RS31360 | 133785..134411 | + | 627 | WP_004197649.1 | ParA family plasmid-partitioning AAA ATPase | - |
| KONIH1_RS35595 | 134408..134710 | + | 303 | WP_071571079.1 | hypothetical protein | - |
| KONIH1_RS31370 | 135142..135936 | - | 795 | WP_004197635.1 | site-specific integrase | - |
| KONIH1_RS31375 | 136134..137150 | - | 1017 | WP_017899884.1 | hypothetical protein | - |
| KONIH1_RS33770 | 137161..137475 | - | 315 | WP_053389906.1 | hypothetical protein | - |
| KONIH1_RS31380 | 137502..137897 | - | 396 | WP_017899885.1 | hypothetical protein | - |
| KONIH1_RS31385 | 138066..138371 | - | 306 | WP_013023785.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| KONIH1_RS31390 | 138373..138591 | - | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| KONIH1_RS33780 | 138761..139222 | - | 462 | WP_162763201.1 | hypothetical protein | - |
| KONIH1_RS31395 | 139179..139409 | + | 231 | WP_001261282.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| KONIH1_RS31400 | 139406..139822 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | - |
| KONIH1_RS31405 | 139896..140132 | + | 237 | WP_001348075.1 | AAA family ATPase | - |
| KONIH1_RS31410 | 140179..140883 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| KONIH1_RS33785 | 140933..141157 | - | 225 | Protein_165 | DUF4158 domain-containing protein | - |
| KONIH1_RS31420 | 141321..141878 | + | 558 | WP_001217881.1 | recombinase family protein | - |
| KONIH1_RS31425 | 142112..142666 | + | 555 | WP_014454105.1 | aminoglycoside N-acetyltransferase AAC(6')-Ib' | - |
| KONIH1_RS31430 | 142736..143524 | + | 789 | WP_001206315.1 | ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / aph(3'')-Ib / aph(6)-Id / blaKPC-2 / aac(6')-Ib / ant(3'')-Ia / blaOXA-9 | - | 1..205586 | 205586 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11615.30 Da Isoelectric Point: 6.4672
>T47465 WP_013023785.1 NZ_CP008791:c138371-138066 [Klebsiella oxytoca KONIH1]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T47465 NZ_CP008791:c138371-138066 [Klebsiella oxytoca KONIH1]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8392.34 Da Isoelectric Point: 4.7405
>AT47465 WP_001568025.1 NZ_CP008791:c138591-138373 [Klebsiella oxytoca KONIH1]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT47465 NZ_CP008791:c138591-138373 [Klebsiella oxytoca KONIH1]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4ZZW6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4ZZP8 |