Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 172626..173197 Replicon plasmid pKOX-86d
Accession NZ_CP008790
Organism Klebsiella oxytoca KONIH1

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag KONIH1_RS33625 Protein ID WP_011918375.1
Coordinates 172886..173197 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag KONIH1_RS30540 Protein ID WP_011787805.1
Coordinates 172626..172886 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KONIH1_RS30515 167835..168464 + 630 WP_044489169.1 3'-5' exonuclease -
KONIH1_RS30520 168916..170406 + 1491 WP_011787801.1 SulP family inorganic anion transporter -
KONIH1_RS30525 170441..171295 + 855 WP_011787802.1 universal stress protein -
KONIH1_RS30530 171386..171718 + 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
KONIH1_RS30535 171836..172456 - 621 WP_011787804.1 recombinase family protein -
KONIH1_RS30540 172626..172886 + 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KONIH1_RS33625 172886..173197 + 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KONIH1_RS30545 173221..176301 + 3081 WP_011787830.1 Tn3 family transposase -
KONIH1_RS30550 176355..176645 + 291 Protein_200 3'-5' exonuclease -
KONIH1_RS30555 176642..177133 + 492 WP_000139717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaFOX-5 / blaCARB-2 / aadA2 / cmlA1 / qacE / sul1 / qnrA1 / dfrA19 / ant(2'')-Ia / catB3 / msr(E) / mph(E) - 1..193725 193725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T47464 WP_011918375.1 NZ_CP008790:172886-173197 [Klebsiella oxytoca KONIH1]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T47464 NZ_CP008790:172886-173197 [Klebsiella oxytoca KONIH1]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT47464 WP_011787805.1 NZ_CP008790:172626-172886 [Klebsiella oxytoca KONIH1]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT47464 NZ_CP008790:172626-172886 [Klebsiella oxytoca KONIH1]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References