Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 43637..44208 Replicon plasmid pKOX-137
Accession NZ_CP008789
Organism Klebsiella oxytoca KONIH1

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag KONIH1_RS33435 Protein ID WP_011918375.1
Coordinates 43637..43948 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag KONIH1_RS29055 Protein ID WP_011787805.1
Coordinates 43948..44208 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KONIH1_RS29045 38973..39977 + 1005 WP_000427619.1 IS110-like element IS5075 family transposase -
KONIH1_RS29050 40533..43613 - 3081 WP_011787830.1 Tn3 family transposase -
KONIH1_RS33435 43637..43948 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KONIH1_RS29055 43948..44208 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KONIH1_RS29060 44378..44998 + 621 WP_011787804.1 recombinase family protein -
KONIH1_RS29065 45116..45448 - 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
KONIH1_RS29070 45539..46393 - 855 WP_011787802.1 universal stress protein -
KONIH1_RS29075 46428..47918 - 1491 WP_011787801.1 SulP family inorganic anion transporter -
KONIH1_RS34845 48416..48909 - 494 Protein_56 IS3-like element ISSen4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..133397 133397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T47462 WP_011918375.1 NZ_CP008789:c43948-43637 [Klebsiella oxytoca KONIH1]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T47462 NZ_CP008789:c43948-43637 [Klebsiella oxytoca KONIH1]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT47462 WP_011787805.1 NZ_CP008789:c44208-43948 [Klebsiella oxytoca KONIH1]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT47462 NZ_CP008789:c44208-43948 [Klebsiella oxytoca KONIH1]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References