Detailed information of TA system TA047458

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 5178474..5179131
• Replicon: chromosome
• Accession: NZ_CP008788
• Organism: Klebsiella oxytoca KONIH1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KONIH1_RS24160
• Protein ID: WP_042946033.1
• Coordinates: 5178474..5178884 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: H3N295
• Locus tag: KONIH1_RS24165
• Protein ID: WP_004124953.1
• Coordinates: 5178865..5179131 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KONIH1_RS24140	5174451..5176184	-	1734	WP_038423602.1	single-stranded-DNA-specific exonuclease RecJ	-
KONIH1_RS24145	5176190..5176903	-	714	WP_004854054.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KONIH1_RS24150	5176926..5177822	-	897	WP_004105555.1	site-specific tyrosine recombinase XerD	-
KONIH1_RS24155	5177944..5178465	+	522	WP_014226792.1	flavodoxin FldB	-
KONIH1_RS24160	5178474..5178884	-	411	WP_042946033.1	protein YgfX	Toxin
KONIH1_RS24165	5178865..5179131	-	267	WP_004124953.1	FAD assembly factor SdhE	Antitoxin
KONIH1_RS24170	5179376..5180359	+	984	WP_032720095.1	tRNA-modifying protein YgfZ	-
KONIH1_RS24175	5180553..5183351	+	2799	WP_014226794.1	transcriptional regulator DagR	-
KONIH1_RS24180	5183472..5183897	+	426	WP_032720093.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16137.00 Da
• Isoelectric Point: 10.9455

>T47458 WP_042946033.1 NZ_CP008788:c5178884-5178474 [Klebsiella oxytoca KONIH1]
VVLWQSDLRISWRAQWFSLLMHGVVATLVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Nucleotide

• Length: 411 bp

>T47458 NZ_CP008788:c5178884-5178474 [Klebsiella oxytoca KONIH1]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGAC
GCTTGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10411.88 Da
• Isoelectric Point: 5.1296

>AT47458 WP_004124953.1 NZ_CP008788:c5179131-5178865 [Klebsiella oxytoca KONIH1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT47458 NZ_CP008788:c5179131-5178865 [Klebsiella oxytoca KONIH1]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGATAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3H3L9