Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4707773..4708326 Replicon chromosome
Accession NZ_CP008788
Organism Klebsiella oxytoca KONIH1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KONIH1_RS21905 Protein ID WP_016157234.1
Coordinates 4707773..4708087 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KONIH1_RS21910 Protein ID WP_016157235.1
Coordinates 4708090..4708326 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KONIH1_RS21890 4702790..4703770 + 981 WP_016947617.1 IS5-like element ISKpn26 family transposase -
KONIH1_RS33015 4703920..4704150 + 231 Protein_4355 kikA from plasmid origin -
KONIH1_RS33020 4704197..4704502 + 306 WP_016157231.1 hypothetical protein -
KONIH1_RS21895 4705279..4707015 + 1737 WP_042945862.1 type IV secretory system conjugative DNA transfer family protein -
KONIH1_RS21900 4707024..4707776 + 753 WP_016157233.1 hypothetical protein -
KONIH1_RS21905 4707773..4708087 - 315 WP_016157234.1 CcdB family protein Toxin
KONIH1_RS21910 4708090..4708326 - 237 WP_016157235.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KONIH1_RS21915 4708649..4709593 - 945 WP_042945864.1 DUF1738 domain-containing protein -
KONIH1_RS21920 4710058..4711266 + 1209 WP_042945865.1 hypothetical protein -
KONIH1_RS21925 4711263..4711769 + 507 WP_032931759.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4615629..4774328 158699
- flank IS/Tn - - 4702790..4703770 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11415.29 Da        Isoelectric Point: 8.9025

>T47457 WP_016157234.1 NZ_CP008788:c4708087-4707773 [Klebsiella oxytoca KONIH1]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQLNRRIVIPLLPAGRYPAGRRPERLVPVVRLTDGQEYAVMTHELASVPVRALG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T47457 NZ_CP008788:c4708087-4707773 [Klebsiella oxytoca KONIH1]
ATGCAGTTCACCGTATACGGAAACACCGGTAAAAGCGCCGTTTACCCTCTGCTGCTTGATGTCACGAGCGATATTATCGG
ACAACTGAACCGCCGGATCGTGATCCCGCTGCTGCCTGCTGGCAGGTATCCGGCAGGACGCCGCCCGGAGCGTCTTGTCC
CTGTCGTCAGACTGACAGACGGTCAGGAATACGCGGTCATGACCCACGAACTGGCGAGTGTCCCTGTCCGGGCGCTGGGA
GCGGTTTTCTGCGATGCGTCTCAATACCGCACTCAGGTGAAGGCCGCCATCGATTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9044.08 Da        Isoelectric Point: 6.2206

>AT47457 WP_016157235.1 NZ_CP008788:c4708326-4708090 [Klebsiella oxytoca KONIH1]
MTAKQRSTQSVTMTVERALLIRAREAGINLSATLTTALDAELRHYEAKKWQEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT47457 NZ_CP008788:c4708326-4708090 [Klebsiella oxytoca KONIH1]
ATGACCGCGAAACAACGCAGCACGCAGAGTGTGACCATGACGGTAGAGCGCGCCTTACTGATCCGGGCACGTGAGGCAGG
CATTAACCTCAGTGCGACCCTGACAACCGCCCTGGATGCGGAGCTTCGCCACTATGAAGCGAAAAAATGGCAGGAAGAGA
ACCGGGAGGCCATCGACGCATTAAATCGTTTCCATGATGAGCATGGCTGTTTCAGTGATGAATACCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References