Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1266804..1267586 Replicon chromosome
Accession NZ_CP008788
Organism Klebsiella oxytoca KONIH1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KONIH1_RS05885 Protein ID WP_042944403.1
Coordinates 1267212..1267586 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KONIH1_RS05880 Protein ID WP_042944401.1
Coordinates 1266804..1267160 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KONIH1_RS35455 1262188..1262337 + 150 WP_001458941.1 hypothetical protein -
KONIH1_RS05840 1262349..1262564 + 216 WP_042944388.1 hypothetical protein -
KONIH1_RS32275 1262617..1263561 + 945 WP_077255291.1 hypothetical protein -
KONIH1_RS05850 1263649..1263882 + 234 WP_042944390.1 DUF905 domain-containing protein -
KONIH1_RS05855 1263993..1264814 + 822 WP_042944391.1 DUF945 domain-containing protein -
KONIH1_RS05860 1264895..1265365 + 471 WP_023567995.1 antirestriction protein -
KONIH1_RS05865 1265377..1265856 + 480 WP_042944395.1 DNA repair protein RadC -
KONIH1_RS05870 1265871..1266092 + 222 WP_042944397.1 DUF987 domain-containing protein -
KONIH1_RS05875 1266108..1266752 + 645 WP_042944399.1 hypothetical protein -
KONIH1_RS05880 1266804..1267160 + 357 WP_042944401.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KONIH1_RS05885 1267212..1267586 + 375 WP_042944403.1 TA system toxin CbtA family protein Toxin
KONIH1_RS05890 1267682..1268059 + 378 WP_042944406.1 TA system toxin CbtA family protein -
KONIH1_RS05895 1268056..1268547 + 492 WP_042944408.1 hypothetical protein -
KONIH1_RS05900 1268574..1268777 + 204 WP_023568001.1 DUF957 domain-containing protein -
KONIH1_RS32280 1268859..1269705 + 847 Protein_1153 DUF4942 domain-containing protein -
KONIH1_RS05915 1269995..1271248 - 1254 WP_014228088.1 glutamate-5-semialdehyde dehydrogenase -
KONIH1_RS05920 1271259..1272362 - 1104 WP_004848066.1 glutamate 5-kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(18-110)

Antitoxin

Antitoxin CbeA

(15-113)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13571.26 Da        Isoelectric Point: 4.5407

>T47446 WP_042944403.1 NZ_CP008788:1267212-1267586 [Klebsiella oxytoca KONIH1]
MRIYPVSAKRAAEIERLSPVSPVAVWQRLLTYLLDRHYGLTLNDTQFGDDGTIQECIDVGDPLLDALNEVVEDDELERTD
NRGKSLLFRSSLLTPADIRNAQKAVGLAGNSASLIISGQSSARS

Download         Length: 375 bp

>T47446 NZ_CP008788:1267212-1267586 [Klebsiella oxytoca KONIH1]
ATGAGAATTTATCCTGTATCCGCAAAACGGGCCGCTGAGATTGAGCGGTTATCGCCTGTGTCACCGGTTGCCGTCTGGCA
GCGCCTCCTGACGTACCTGCTGGACCGTCACTACGGTCTGACGCTTAACGATACTCAGTTTGGCGATGACGGCACCATTC
AGGAATGCATTGACGTCGGTGATCCCCTGCTTGACGCCCTGAACGAAGTGGTTGAAGACGACGAGCTGGAGCGTACTGAT
AACCGGGGAAAATCACTTCTGTTCAGATCGTCGCTGCTCACACCCGCAGATATCCGGAACGCCCAGAAAGCCGTGGGTCT
GGCAGGCAACAGCGCCTCCCTCATTATCAGCGGTCAGTCGTCAGCCAGAAGCTAA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13079.82 Da        Isoelectric Point: 6.3170

>AT47446 WP_042944401.1 NZ_CP008788:1266804-1267160 [Klebsiella oxytoca KONIH1]
MPDIPATNDNMDAPRWGLQRNITPCFGARLVQEGNRLHYLADRASINGTFSDADLRHLDQSFPLLLKQLELMLVSGELNP
RHQHSVTLYAKGLTCEADSLASHGYVYIAIYPTPATTA

Download         Length: 357 bp

>AT47446 NZ_CP008788:1266804-1267160 [Klebsiella oxytoca KONIH1]
ATGCCAGATATCCCTGCCACAAATGACAATATGGACGCGCCGCGCTGGGGTCTTCAGCGCAATATCACGCCCTGTTTTGG
CGCTCGCCTGGTGCAGGAGGGCAACCGGCTGCATTACCTGGCTGACCGCGCCAGTATCAACGGAACCTTCAGCGATGCGG
ATTTACGCCATCTCGACCAGTCGTTTCCGCTGCTGTTGAAACAACTGGAACTGATGCTGGTTTCCGGTGAACTCAATCCC
CGTCATCAACACAGCGTTACGCTTTACGCAAAAGGGCTGACCTGCGAGGCCGACAGCCTCGCTTCGCACGGGTACGTCTA
TATCGCAATTTATCCGACACCAGCCACAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References