Detailed information of TA system TA047445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 1196492..1197311
• Replicon: chromosome
• Accession: NZ_CP008788
• Organism: Klebsiella oxytoca KONIH1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: KONIH1_RS05525
• Protein ID: WP_004110819.1
• Coordinates: 1196492..1196749 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: KONIH1_RS05530
• Protein ID: WP_042944337.1
• Coordinates: 1196760..1197311 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KONIH1_RS05510	1192168..1192944	-	777	WP_004847986.1	Uxu operon transcriptional regulator	-
KONIH1_RS05515	1193083..1194558	-	1476	WP_014228053.1	fructuronate reductase	-
KONIH1_RS05520	1194632..1195816	-	1185	WP_014228054.1	mannonate dehydratase	-
KONIH1_RS05525	1196492..1196749	+	258	WP_004110819.1	YjhX family toxin	Toxin
KONIH1_RS05530	1196760..1197311	+	552	WP_042944337.1	N-acetyltransferase	Antitoxin
KONIH1_RS05535	1197329..1198957	+	1629	WP_014837490.1	SAM-dependent methyltransferase	-
KONIH1_RS34995	1198991..1199149	+	159	Protein_1079	hypothetical protein	-
KONIH1_RS05545	1199146..1199561	+	416	Protein_1080	type II toxin-antitoxin system VapC family toxin	-
KONIH1_RS05550	1199830..1200303	-	474	WP_032693194.1	hypothetical protein	-
KONIH1_RS05555	1200614..1201387	-	774	WP_103433587.1	Zygote formation protein zyg1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T47445 WP_004110819.1 NZ_CP008788:1196492-1196749 [Klebsiella oxytoca KONIH1]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T47445 NZ_CP008788:1196492-1196749 [Klebsiella oxytoca KONIH1]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19872.62 Da
• Isoelectric Point: 6.3261

>AT47445 WP_042944337.1 NZ_CP008788:1196760-1197311 [Klebsiella oxytoca KONIH1]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAACYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCAWALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT47445 NZ_CP008788:1196760-1197311 [Klebsiella oxytoca KONIH1]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTGCTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCTGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2