Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 1574739..1575276 Replicon chromosome
Accession NZ_CP008786
Organism Burkholderia thailandensis E264

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag DR63_RS26600 Protein ID WP_004549731.1
Coordinates 1575007..1575276 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q2T6G1
Locus tag DR63_RS26595 Protein ID WP_011401115.1
Coordinates 1574739..1575023 (-) Length 95 a.a.

Genomic Context

DR63_RS26570DR63_RS26575DR63_RS26580DR63_RS26585DR63_RS26595DR63_RS26600DR63_RS26605DR63_RS26610DR63_RS26615DR63_RS26625DR63_RS26630DR63_RS26635DR63_RS26640DR63_RS26645
Location: 1569764..1570606 (843 bp)
Type: Others
Protein ID: WP_011401119.1
Location: 1570584..1571879 (1296 bp)
Type: Others
Protein ID: WP_009896509.1
Location: 1571887..1573629 (1743 bp)
Type: Others
Protein ID: WP_011401117.1
Location: 1573629..1574108 (480 bp)
Type: Others
Protein ID: WP_025404174.1
Location: 1574739..1575023 (285 bp)
Type: Antitoxin
Protein ID: WP_011401115.1
Location: 1575007..1575276 (270 bp)
Type: Toxin
Protein ID: WP_004549731.1
Location: 1575326..1575769 (444 bp)
Type: Others
Protein ID: WP_009896499.1
Location: 1575766..1576026 (261 bp)
Type: Others
Protein ID: WP_009896498.1
Location: 1576002..1576334 (333 bp)
Type: Others
Protein ID: WP_011401114.1
Location: 1576774..1577130 (357 bp)
Type: Others
Protein ID: WP_009896497.1
Location: 1577127..1577678 (552 bp)
Type: Others
Protein ID: WP_011401112.1
Location: 1577675..1578667 (993 bp)
Type: Others
Protein ID: WP_015967393.1
Location: 1578821..1579081 (261 bp)
Type: Others
Protein ID: WP_004526650.1
Location: 1579078..1579899 (822 bp)
Type: Others
Protein ID: WP_009896491.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DR63_RS265701569764..1570606-843WP_011401119.1Clp protease ClpP-
DR63_RS265751570584..1571879-1296WP_009896509.1phage portal protein-
DR63_RS265801571887..1573629-1743WP_011401117.1terminase large subunit-
DR63_RS265851573629..1574108-480WP_025404174.1terminase small subunit-
DR63_RS265951574739..1575023-285WP_011401115.1BrnA antitoxin family proteinAntitoxin
DR63_RS266001575007..1575276-270WP_004549731.1BrnT family toxinToxin
DR63_RS266051575326..1575769-444WP_009896499.1hypothetical protein-
DR63_RS266101575766..1576026-261WP_009896498.1hypothetical protein-
DR63_RS266151576002..1576334-333WP_011401114.1hypothetical protein-
DR63_RS266251576774..1577130-357WP_009896497.1hypothetical protein-
DR63_RS266301577127..1577678-552WP_011401112.1DUF1064 domain-containing protein-
DR63_RS266351577675..1578667-993WP_015967393.1hypothetical protein-
DR63_RS266401578821..1579081-261WP_004526650.1helix-turn-helix domain-containing protein-
DR63_RS266451579078..1579899-822WP_009896491.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1550065..159470844643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T47442 WP_004549731.1 NZ_CP008786:c1575276-1575007 [Burkholderia thailandensis E264]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T47442 NZ_CP008786:c1575276-1575007 [Burkholderia thailandensis E264]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10669.09 Da        Isoelectric Point: 5.8930

>AT47442 WP_011401115.1 NZ_CP008786:c1575023-1574739 [Burkholderia thailandensis E264]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLKEHQPA

Download         Length: 285 bp

>AT47442 NZ_CP008786:c1575023-1574739 [Burkholderia thailandensis E264]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTACGACGTCGACATCGTGGACGCCTTCAAGGCAACAGGCGAAGGTTGGCAGACGCGTATG
AATGATGCGTTGCGCGAGTGGCTGAAGGAGCACCAGCCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ2T6G2

Antitoxin

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Source
ID
Structure
AlphaFold DBQ2T6G1

References