Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 346372..347011 Replicon chromosome
Accession NZ_CP008786
Organism Burkholderia thailandensis E264

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag DR63_RS21295 Protein ID WP_009893919.1
Coordinates 346372..346551 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q2T3Q7
Locus tag DR63_RS21300 Protein ID WP_011401461.1
Coordinates 346595..347011 (+) Length 139 a.a.

Genomic Context

DR63_RS21270DR63_RS21275DR63_RS21295DR63_RS21300DR63_RS21280DR63_RS21285DR63_RS21290DR63_RS21310DR63_RS21315DR63_RS21320
Location: 341761..342741 (981 bp)
Type: Others
Protein ID: WP_043037760.1
Location: 343063..343638 (576 bp)
Type: Others
Protein ID: WP_009893925.1
Location: 346372..346551 (180 bp)
Type: Toxin
Protein ID: WP_009893919.1
Location: 346595..347011 (417 bp)
Type: Antitoxin
Protein ID: WP_011401461.1
Location: 343709..344824 (1116 bp)
Type: Others
Protein ID: WP_009893924.1
Location: 344834..345568 (735 bp)
Type: Others
Protein ID: WP_011401463.1
Location: 345565..346092 (528 bp)
Type: Others
Protein ID: WP_011401462.1
Location: 347440..347937 (498 bp)
Type: Others
Protein ID: WP_011401460.1
Location: 348556..349128 (573 bp)
Type: Others
Protein ID: WP_009893915.1
Location: 349181..349915 (735 bp)
Type: Others
Protein ID: WP_009893914.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DR63_RS21270341761..342741+981WP_043037760.1DUF3644 domain-containing protein-
DR63_RS21275343063..343638+576WP_009893925.1recombinase family protein-
DR63_RS21280343709..344824-1116WP_009893924.1DUF3396 domain-containing protein-
DR63_RS21285344834..345568-735WP_011401463.1VRR-NUC domain-containing protein-
DR63_RS21290345565..346092-528WP_011401462.1PAAR domain-containing protein-
DR63_RS21295346372..346551+180WP_009893919.1type II toxin-antitoxin system HicA family toxinToxin
DR63_RS21300346595..347011+417WP_011401461.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
DR63_RS21310347440..347937-498WP_011401460.1hypothetical protein-
DR63_RS21315348556..349128-573WP_009893915.1site-specific integrase-
DR63_RS21320349181..349915-735WP_009893914.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--327441..34701119570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T47440 WP_009893919.1 NZ_CP008786:346372-346551 [Burkholderia thailandensis E264]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T47440 NZ_CP008786:346372-346551 [Burkholderia thailandensis E264]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGTCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.03 Da        Isoelectric Point: 4.6944

>AT47440 WP_011401461.1 NZ_CP008786:346595-347011 [Burkholderia thailandensis E264]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGDDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT47440 NZ_CP008786:346595-347011 [Burkholderia thailandensis E264]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GGGACGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTTGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB4C26
PDB6G26

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ2T3Q7

References