Detailed information of TA system TA047437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1186807..1187363
• Replicon: chromosome
• Accession: NZ_CP008784
• Organism: Burkholderia pseudomallei MSHR5855

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DP63_RS18500
• Protein ID: WP_024429387.1
• Coordinates: 1187073..1187363 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: DP63_RS18495
• Protein ID: WP_004541313.1
• Coordinates: 1186807..1187085 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DP63_RS39890	1182325..1183605	+	1281	WP_144399190.1	hypothetical protein	-
DP63_RS36530	1183652..1183942	-	291	WP_071897845.1	hypothetical protein	-
DP63_RS18480	1184431..1184700	+	270	WP_020850841.1	ribbon-helix-helix protein, CopG family	-
DP63_RS18490	1184703..1186727	+	2025	WP_075018821.1	relaxase/mobilization nuclease domain-containing protein	-
DP63_RS18495	1186807..1187085	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
DP63_RS18500	1187073..1187363	+	291	WP_024429387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DP63_RS18505	1187360..1187680	+	321	WP_024429388.1	hypothetical protein	-
DP63_RS39895	1187876..1188124	+	249	WP_080251141.1	hypothetical protein	-
DP63_RS41480	1188229..1188888	+	660	WP_024429389.1	hypothetical protein	-
DP63_RS18515	1188930..1191134	-	2205	WP_024429390.1	AAA family ATPase	-
DP63_RS18520	1191361..1191882	-	522	WP_024429391.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1174245..1196229	21984

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10906.47 Da
• Isoelectric Point: 9.5554

>T47437 WP_024429387.1 NZ_CP008784:1187073-1187363 [Burkholderia pseudomallei MSHR5855]
MPQVIFAPAAIGDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T47437 NZ_CP008784:1187073-1187363 [Burkholderia pseudomallei MSHR5855]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCCTCGATGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCAGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT47437 WP_004541313.1 NZ_CP008784:1186807-1187085 [Burkholderia pseudomallei MSHR5855]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT47437 NZ_CP008784:1186807-1187085 [Burkholderia pseudomallei MSHR5855]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCACTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGTGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0