Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1596722..1597334 Replicon chromosome
Accession NZ_CP008776
Organism Streptococcus pyogenes strain 5448

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag SP5448_RS08060 Protein ID WP_010922665.1
Coordinates 1596999..1597334 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag SP5448_RS08055 Protein ID WP_002988079.1
Coordinates 1596722..1597009 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SP5448_RS08030 1591899..1592882 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
SP5448_RS08035 1592886..1593815 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
SP5448_RS08040 1593863..1594378 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
SP5448_RS08045 1594413..1594841 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
SP5448_RS08050 1595288..1596061 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
SP5448_RS08055 1596722..1597009 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
SP5448_RS08060 1596999..1597334 + 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SP5448_RS09490 1597486..1597668 + 183 WP_011285716.1 integrase -
SP5448_RS09495 1598002..1598439 + 438 WP_076639988.1 site-specific integrase -
SP5448_RS08070 1598559..1598951 - 393 WP_002982716.1 30S ribosomal protein S9 -
SP5448_RS08075 1598972..1599418 - 447 WP_002982710.1 50S ribosomal protein L13 -
SP5448_RS08080 1599636..1599842 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
SP5448_RS08085 1599839..1600345 - 507 WP_002988070.1 hypothetical protein -
SP5448_RS08090 1600481..1601341 - 861 WP_002982687.1 DegV family protein -
SP5448_RS08095 1601438..1601956 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T47422 WP_010922665.1 NZ_CP008776:1596999-1597334 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T47422 NZ_CP008776:1596999-1597334 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT47422 WP_002988079.1 NZ_CP008776:1596722-1597009 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT47422 NZ_CP008776:1596722-1597009 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References