Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1223688..1225463 Replicon chromosome
Accession NZ_CP008762
Organism Paraburkholderia xenovorans LB400

Toxin (Protein)


Gene name doc Uniprot ID Q13JH4
Locus tag DR64_RS33665 Protein ID WP_011493035.1
Coordinates 1223688..1224578 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q13JH5
Locus tag DR64_RS33670 Protein ID WP_011493034.1
Coordinates 1224579..1225463 (+) Length 295 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR64_RS33635 1219048..1220121 - 1074 WP_011493040.1 porin -
DR64_RS33640 1220561..1220875 + 315 WP_006047381.1 non-heme iron oxygenase ferredoxin subunit -
DR64_RS33645 1220877..1221188 + 312 WP_011493039.1 hypothetical protein -
DR64_RS33650 1221237..1222328 + 1092 WP_011493038.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DR64_RS33655 1222321..1223088 + 768 WP_011493037.1 SDR family oxidoreductase -
DR64_RS33660 1223115..1223642 + 528 WP_011493036.1 cupin domain-containing protein -
DR64_RS33665 1223688..1224578 + 891 WP_011493035.1 alpha/beta fold hydrolase Toxin
DR64_RS33670 1224579..1225463 + 885 WP_011493034.1 IclR family transcriptional regulator Antitoxin
DR64_RS33675 1225463..1226272 + 810 WP_011493033.1 SDR family oxidoreductase -
DR64_RS33680 1226265..1227923 + 1659 WP_011493032.1 thiamine pyrophosphate-binding protein -
DR64_RS33685 1227916..1228746 + 831 WP_011493031.1 aspartate dehydrogenase -
DR64_RS33690 1228787..1230277 + 1491 WP_040125124.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-279)

Antitoxin

Transcription regulator IclR, C-terminal

(148-272)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 31104.21 Da        Isoelectric Point: 7.2072

>T47418 WP_011493035.1 NZ_CP008762:1223688-1224578 [Paraburkholderia xenovorans LB400]
MSAVPSVTADAHATLEARVARFPTQQIWLASQRAVSYREVDGAGSGALPLVLLHGIGSGAASWVQQFEMLGATRRVLAWD
APGYGASTPVAADSPAAADYASVLKEWLDALGIERCVLLGHSLGAIIAGAFAVTHAQRVAGLLLLSPAGGYGAASAEVRN
TKRDQRLAMLNELGPQGLAEQRSTNMLSAHASDEARAWVRWNMARVIPHGYAQATHLLANADLASDLARHQGRINVAVGA
DDTITTPEACERIALAARTKLQVVPRAGHAGYIEAPAAYTAIIDTFCRASDGQRSQ

Download         Length: 891 bp

>T47418 NZ_CP008762:1223688-1224578 [Paraburkholderia xenovorans LB400]
ATGTCCGCTGTTCCATCCGTTACCGCAGATGCACACGCCACGCTCGAAGCGCGCGTTGCGCGTTTCCCGACGCAGCAGAT
CTGGTTGGCGTCGCAACGTGCGGTGAGCTATCGCGAAGTGGATGGCGCCGGTAGCGGTGCGCTGCCGCTCGTGCTGCTGC
ACGGTATCGGTTCGGGCGCGGCGTCGTGGGTGCAGCAGTTCGAAATGCTCGGCGCGACGCGCCGCGTGCTGGCGTGGGAT
GCGCCGGGTTATGGCGCCTCCACGCCGGTCGCGGCCGACTCGCCAGCCGCGGCTGACTACGCGAGCGTGCTGAAAGAGTG
GCTCGACGCGCTCGGCATTGAACGCTGCGTGCTGCTCGGTCATTCGCTCGGCGCGATTATCGCCGGCGCGTTTGCCGTGA
CGCATGCGCAGCGCGTGGCCGGCTTGCTGCTGTTGTCGCCGGCTGGCGGTTACGGCGCGGCATCGGCAGAGGTACGCAAC
ACGAAGCGCGATCAGCGGCTCGCGATGCTGAACGAACTCGGCCCGCAAGGTCTCGCCGAACAACGCAGCACGAATATGTT
GTCCGCTCACGCAAGCGACGAAGCTCGCGCATGGGTGCGCTGGAACATGGCGCGCGTGATCCCGCACGGTTACGCGCAGG
CCACGCATCTGCTCGCCAACGCCGATCTCGCGAGCGACCTCGCGCGCCACCAGGGCCGCATCAACGTGGCCGTGGGCGCC
GACGACACCATTACCACGCCCGAAGCCTGCGAACGCATCGCGCTGGCCGCGCGCACCAAGTTGCAGGTCGTGCCTCGGGC
GGGGCACGCCGGCTATATCGAAGCACCCGCCGCGTACACCGCGATCATCGACACGTTCTGTCGCGCGAGCGACGGACAAC
GGAGCCAATGA

Antitoxin


Download         Length: 295 a.a.        Molecular weight: 32693.22 Da        Isoelectric Point: 6.9988

>AT47418 WP_011493034.1 NZ_CP008762:1224579-1225463 [Paraburkholderia xenovorans LB400]
MTPDTINAERDADEDRNDTTGDTAYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLERAD
KDRNYRLGVAVLRLGFEYLSSLELTDLGLPVIEALRTETGLTSHIVIRDGRDVVFVAKAQSHTPIFSSVKVNVGTRLPAH
ATTHGQVLMGDLTLDDLKKLYPEPELERFTKQTPITVDDLYERIRDDARRGFAISESSFERGISVVSAPVRNETGRIVAV
ITTTIPRHEIDASLLDSGLIDKVRRAADDLSQRLNYRPKSGPNAGSKYMKALGL

Download         Length: 885 bp

>AT47418 NZ_CP008762:1224579-1225463 [Paraburkholderia xenovorans LB400]
ATGACGCCCGACACCATTAACGCCGAGCGCGACGCGGACGAAGACCGCAACGACACCACGGGCGACACCGCCTATCGGGT
GCCGGGTCTCGAACGCGGTCTGAAGATTCTCACCGAGTTCTCGCCACGCGAGCCGGTTCTCGGCGCGCCGGAATTATCGA
AGCGCCTGAAGATTCCTCGCACGACGGTGTTCCGTCTGCTGCAAACCCTCGAATCGCTCGGCTTTCTCGAACGTGCCGAC
AAGGACCGCAACTATCGCCTCGGCGTTGCCGTGCTGCGGCTCGGTTTCGAATATCTGAGCTCGCTCGAACTGACCGACCT
CGGCTTGCCGGTCATCGAAGCGCTGCGTACGGAAACCGGCCTCACCAGCCACATCGTGATCCGCGATGGACGCGACGTCG
TGTTCGTCGCCAAGGCGCAAAGCCATACGCCGATTTTCAGCTCGGTGAAGGTGAACGTGGGCACGCGTCTGCCGGCTCAT
GCCACGACGCACGGGCAGGTGCTGATGGGCGACCTGACACTTGATGACTTGAAGAAGCTCTATCCCGAGCCGGAACTCGA
ACGCTTCACGAAGCAGACGCCCATCACCGTGGACGACCTGTACGAACGGATTCGCGACGACGCGCGGCGCGGTTTCGCGA
TCAGCGAGTCGTCGTTCGAACGCGGCATTTCCGTGGTGAGCGCGCCGGTGCGCAACGAAACGGGACGCATCGTCGCCGTC
ATCACGACGACGATTCCGCGCCACGAGATCGACGCGTCGCTGCTCGACAGCGGCCTGATCGACAAGGTCCGCCGCGCCGC
CGACGATCTTTCGCAGCGGCTCAACTATCGGCCGAAGAGTGGGCCGAATGCGGGCAGCAAATACATGAAGGCATTGGGGC
TCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q13JH4

Antitoxin

Source ID Structure
AlphaFold DB Q13JH5

References