Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 604880..605553 Replicon chromosome
Accession NZ_CP008761
Organism Paraburkholderia xenovorans LB400

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DR64_RS24700 Protein ID WP_011493602.1
Coordinates 605149..605553 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DR64_RS24695 Protein ID WP_040123745.1
Coordinates 604880..605152 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR64_RS24665 600358..600678 - 321 WP_040123545.1 VirB3 family type IV secretion system protein -
DR64_RS24670 600704..601039 - 336 WP_011493608.1 TrbC/VirB2 family protein -
DR64_RS24675 601075..601722 - 648 WP_011493607.1 lytic transglycosylase domain-containing protein -
DR64_RS24680 601719..602297 - 579 WP_011493606.1 hypothetical protein -
DR64_RS24685 602290..603150 - 861 WP_011493605.1 cobyric acid synthase CobQ -
DR64_RS44430 604003..604581 - 579 WP_148223096.1 hypothetical protein -
DR64_RS24695 604880..605152 + 273 WP_040123745.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DR64_RS24700 605149..605553 + 405 WP_011493602.1 type II toxin-antitoxin system VapC family toxin Toxin
DR64_RS24705 605968..606294 - 327 WP_040123546.1 hypothetical protein -
DR64_RS24710 606291..606533 - 243 WP_011493600.1 AlpA family phage regulatory protein -
DR64_RS46255 606854..607024 + 171 WP_158340964.1 hypothetical protein -
DR64_RS24715 607171..608205 - 1035 WP_011493598.1 porin -
DR64_RS24720 608279..608824 - 546 WP_011493597.1 amino acid synthesis family protein -
DR64_RS24725 608821..610236 - 1416 WP_011493596.1 amidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14408.62 Da        Isoelectric Point: 4.8604

>T47417 WP_011493602.1 NZ_CP008761:605149-605553 [Paraburkholderia xenovorans LB400]
MSGYLLDTNIISDMIRNPFGQVAARIEQIDPRAICTSVVVAAELRYGCAKKGSAKLLARVESLLATIPVLPLDVPADTEY
GGIRAELEAAGQPIGANDLLIGAHAYALGLTLVTDNTKEFSRIRGLTIENWLDR

Download         Length: 405 bp

>T47417 NZ_CP008761:605149-605553 [Paraburkholderia xenovorans LB400]
TTGAGCGGCTATCTGCTCGACACGAACATCATCAGCGACATGATCCGGAATCCGTTCGGACAGGTGGCCGCCCGTATTGA
GCAGATTGATCCCAGGGCGATCTGCACGAGCGTCGTCGTCGCGGCGGAACTGCGCTATGGCTGTGCAAAAAAGGGGTCCG
CGAAGTTGCTGGCCAGAGTCGAAAGTCTCCTTGCAACCATTCCCGTGCTGCCGCTGGACGTCCCTGCCGACACGGAATAC
GGGGGCATCCGCGCGGAGCTTGAGGCCGCCGGCCAGCCGATCGGTGCAAACGACCTTTTGATTGGCGCTCATGCCTACGC
ATTGGGGCTGACACTCGTGACTGACAACACGAAAGAGTTCAGCCGCATTCGCGGTCTCACGATCGAGAACTGGCTTGACC
GGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10258.72 Da        Isoelectric Point: 4.6677

>AT47417 WP_040123745.1 NZ_CP008761:604880-605152 [Paraburkholderia xenovorans LB400]
VPIPTPSARPREARLFRNNRSQAVRIPVEFELPGDRVLIHREGDKLIIEPVRTPANIIELLAAWRQELPPGPDDQFPDIE
DPPVRPEDVL

Download         Length: 273 bp

>AT47417 NZ_CP008761:604880-605152 [Paraburkholderia xenovorans LB400]
GTGCCAATCCCAACGCCATCCGCCCGGCCCAGGGAGGCCAGGCTGTTCCGCAACAACCGCAGCCAGGCGGTACGCATCCC
TGTCGAGTTCGAGCTGCCGGGCGATCGCGTTCTGATCCACCGGGAGGGCGACAAGCTCATCATCGAACCGGTGAGGACGC
CCGCGAACATCATCGAACTGCTCGCCGCGTGGAGACAGGAGCTGCCGCCCGGACCTGATGACCAGTTTCCGGATATCGAA
GATCCGCCAGTTCGACCGGAGGACGTACTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References