Detailed information of TA system TA047416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2598177..2598754
• Replicon: chromosome
• Accession: NZ_CP008760
• Organism: Paraburkholderia xenovorans LB400

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: DR64_RS11595
• Protein ID: WP_038458473.1
• Coordinates: 2598177..2598455 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: DR64_RS11600
• Protein ID: WP_011490165.1
• Coordinates: 2598497..2598754 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DR64_RS11575	2593898..2594815	+	918	WP_011490170.1	ABC transporter permease subunit	-
DR64_RS11580	2594815..2595819	+	1005	WP_011490169.1	ABC transporter ATP-binding protein	-
DR64_RS11585	2595816..2596835	+	1020	WP_011490168.1	ABC transporter ATP-binding protein	-
DR64_RS11590	2596828..2597979	+	1152	WP_011490167.1	TraB/GumN family protein	-
DR64_RS11595	2598177..2598455	+	279	WP_038458473.1	BrnT family toxin	Toxin
DR64_RS11600	2598497..2598754	+	258	WP_011490165.1	BrnA antitoxin family protein	Antitoxin
DR64_RS11605	2598894..2600699	-	1806	WP_011490164.1	tetratricopeptide repeat protein	-
DR64_RS11610	2600915..2601871	-	957	WP_011490163.1	DUF979 domain-containing protein	-
DR64_RS11615	2601868..2602617	-	750	WP_011490162.1	DUF969 domain-containing protein	-
DR64_RS11620	2602895..2603647	-	753	WP_011490161.1	5-oxoprolinase subunit PxpA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-82)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (24-77)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10762.17 Da
• Isoelectric Point: 6.4819

>T47416 WP_038458473.1 NZ_CP008760:2598177-2598455 [Paraburkholderia xenovorans LB400]
VQFEWDEAKNQINIRKHGIDFQDAIDVFNHPVLTALDTREDYGEDRWIALGWMAAVVGVVVYVERSADVIRIISARKATR
HELGHYKQRIWN

Nucleotide

• Length: 279 bp

>T47416 NZ_CP008760:2598177-2598455 [Paraburkholderia xenovorans LB400]
GTGCAGTTCGAGTGGGACGAAGCCAAAAATCAAATCAATATCCGCAAACACGGCATCGACTTTCAGGATGCCATCGACGT
GTTCAATCATCCCGTACTTACGGCACTAGACACGCGGGAAGATTACGGCGAGGACCGGTGGATCGCATTGGGCTGGATGG
CGGCTGTCGTGGGCGTGGTGGTGTACGTGGAGCGCAGTGCGGATGTGATCCGGATCATTTCGGCCCGCAAGGCAACCAGG
CACGAACTCGGACATTACAAGCAGCGCATCTGGAATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9943.28 Da
• Isoelectric Point: 9.6907

>AT47416 WP_011490165.1 NZ_CP008760:2598497-2598754 [Paraburkholderia xenovorans LB400]
MGKTSGTDWKRLARTDDAQIDKSDVPELGDEFFERAELHVPPKQAVTMRLDADVLNWFKEQGQGYQTRINKLLRAYMLAH
QRRRP

Nucleotide

• Length: 258 bp

>AT47416 NZ_CP008760:2598497-2598754 [Paraburkholderia xenovorans LB400]
ATGGGCAAAACATCGGGAACGGATTGGAAGCGACTCGCCAGAACGGACGATGCGCAAATCGATAAGAGCGACGTACCTGA
GTTGGGCGACGAGTTTTTTGAGCGCGCCGAACTGCATGTTCCTCCAAAGCAGGCCGTGACAATGCGTCTGGATGCGGACG
TGTTGAACTGGTTCAAGGAGCAAGGTCAAGGCTATCAGACGCGGATCAACAAATTGTTGCGCGCCTATATGCTGGCACAT
CAGCGCCGGCGTCCTTGA