Detailed information of TA system TA047406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 978457..979230
• Replicon: chromosome
• Accession: NZ_CP008747
• Organism: Staphylococcus hyicus strain ATCC 11249

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: SHYC_RS12350
• Protein ID: WP_167693803.1
• Coordinates: 979075..979230 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0A8HNH4
• Locus tag: SHYC_RS04610
• Protein ID: WP_039644857.1
• Coordinates: 978457..979056 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SHYC_RS04590	974766..975488	+	723	WP_039644852.1	amino acid ABC transporter ATP-binding protein	-
SHYC_RS04595	975654..976781	+	1128	WP_039644853.1	tRNA epoxyqueuosine(34) reductase QueG	-
SHYC_RS04600	976784..977254	+	471	WP_039644854.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SHYC_RS04605	977270..978439	+	1170	WP_039644856.1	N-acetylglucosamine-6-phosphate deacetylase	-
SHYC_RS04610	978457..979056	+	600	WP_039644857.1	glucosamine-6-phosphate isomerase	Antitoxin
SHYC_RS12350	979075..979230	+	156	WP_167693803.1	hypothetical protein	Toxin
SHYC_RS04615	979386..979790	+	405	WP_039644859.1	hypothetical protein	-
SHYC_RS04620	979948..981333	+	1386	WP_039644862.1	class II fumarate hydratase	-
SHYC_RS04625	981355..982881	+	1527	WP_039644866.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-72)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5989.31 Da
• Isoelectric Point: 3.9940

>T47406 WP_167693803.1 NZ_CP008747:979075-979230 [Staphylococcus hyicus]
MSEEKHIEHENEMVDNFDDLVQLGKEMEQISETNDQDKLNQSHDSEGRSNQ

Nucleotide

• Length: 156 bp

>T47406 NZ_CP008747:979075-979230 [Staphylococcus hyicus]
ATGTCTGAAGAAAAACATATCGAACATGAAAATGAGATGGTAGATAATTTCGATGATCTTGTGCAATTAGGCAAAGAAAT
GGAACAGATTTCTGAAACAAATGATCAAGACAAATTGAACCAATCACATGACTCTGAGGGACGTTCAAATCAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22363.41 Da
• Isoelectric Point: 6.0248

>AT47406 WP_039644857.1 NZ_CP008747:978457-979056 [Staphylococcus hyicus]
MAMNFKVFKDKDTAAIYAADIIRKQFNNNPTTIAGFHLNEEAAPVLDYLKRNVDDHAVDFSQIHILDYDKQTSYFKALGV
PEKQIHEIPEEDEVEKFIERKAKTKDNKGKLTLQVVSINNKGEFGIPVTNGLKPAREIFVVVTGSEKADVIKKLYEDNGN
TSFIPSSLKAHRMVNVILDEAAAQGLPDDVRAYFTSLYA

Nucleotide

• Length: 600 bp

>AT47406 NZ_CP008747:978457-979056 [Staphylococcus hyicus]
ATGGCAATGAACTTTAAAGTTTTTAAAGACAAAGATACTGCAGCGATTTATGCGGCGGATATCATTAGAAAACAATTCAA
TAATAATCCAACAACGATCGCAGGGTTTCATTTAAATGAGGAAGCGGCACCAGTGCTTGATTATTTAAAGCGTAATGTTG
ATGATCATGCGGTTGATTTTAGTCAAATTCATATTTTAGATTACGATAAACAAACATCATACTTTAAAGCATTAGGTGTA
CCAGAAAAACAAATTCATGAAATTCCAGAAGAAGATGAAGTTGAAAAATTTATTGAACGTAAAGCGAAAACGAAAGACAA
TAAAGGCAAACTTACATTGCAAGTTGTTTCAATCAATAATAAAGGTGAATTTGGTATTCCTGTTACGAATGGTTTAAAGC
CTGCACGTGAAATTTTTGTTGTTGTGACAGGAAGTGAAAAAGCGGATGTCATTAAAAAATTATATGAAGACAATGGTAAT
ACAAGCTTTATTCCTTCAAGTTTAAAAGCTCACCGTATGGTCAATGTCATTCTTGATGAAGCTGCTGCGCAAGGGTTACC
TGATGATGTAAGAGCGTACTTCACTTCACTTTATGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A0A8HNH4