Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 840211..840735 Replicon chromosome
Accession NZ_CP008747
Organism Staphylococcus hyicus strain ATCC 11249

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag SHYC_RS03830 Protein ID WP_037567539.1
Coordinates 840382..840735 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0A8HN67
Locus tag SHYC_RS03825 Protein ID WP_039644674.1
Coordinates 840211..840381 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SHYC_RS11815 836006..836482 + 477 WP_052257801.1 PH domain-containing protein -
SHYC_RS03805 836475..837965 + 1491 WP_039644671.1 PH domain-containing protein -
SHYC_RS03810 837946..838461 + 516 WP_082021528.1 PH domain-containing protein -
SHYC_RS03815 838529..838879 + 351 WP_039644672.1 holo-ACP synthase -
SHYC_RS03820 838979..840127 + 1149 WP_039644673.1 alanine racemase -
SHYC_RS03825 840211..840381 + 171 WP_039644674.1 hypothetical protein Antitoxin
SHYC_RS03830 840382..840735 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SHYC_RS03835 840794..841798 + 1005 WP_039644675.1 PP2C family protein-serine/threonine phosphatase -
SHYC_RS03840 841879..842205 + 327 WP_039644676.1 anti-sigma factor antagonist -
SHYC_RS03845 842208..842687 + 480 WP_039644678.1 anti-sigma B factor RsbW -
SHYC_RS03850 842662..843432 + 771 WP_039644680.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T47405 WP_037567539.1 NZ_CP008747:840382-840735 [Staphylococcus hyicus]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T47405 NZ_CP008747:840382-840735 [Staphylococcus hyicus]
ATGAAACGTGGCGACGTTTATTTAGCAGATTTATCGCCAGTACAAGGGTCGGAACAAGGGGGAGTCAGACCTGTCGTTAT
CATTCAAAATGATACTGGCAACAAGTATAGTCCAACTGTTATTGTTGCTGCAATTACTGGACGAATTAATAAAGCTAAAA
TTCCAACACATGTTGAAATTGAAAAACATAAGTATAAGCTCGATAAAGACTCTGTTATCTTATTAGAACAAATAAGGACA
GTTGATAAGAAGAGGCTTAAAGAAAAGTTGACCTATCTTTCGGATAAAAAAATGAAAGAAGTAAACGCAGCACTTGGAAT
TAGTCTAGGATTGCACATGAACCAACATAAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6277.94 Da        Isoelectric Point: 4.0644

>AT47405 WP_039644674.1 NZ_CP008747:840211-840381 [Staphylococcus hyicus]
MSAFYQTRGKSLEQLLKEGYVQMADLNLSLATEAYSVECEACDCNESHLLSNNKDD

Download         Length: 171 bp

>AT47405 NZ_CP008747:840211-840381 [Staphylococcus hyicus]
ATGTCAGCATTCTATCAAACAAGAGGTAAAAGCTTAGAACAATTGTTAAAAGAAGGGTATGTTCAGATGGCAGATTTAAA
TCTCTCCCTAGCAACAGAAGCATACTCCGTTGAATGTGAAGCTTGTGATTGTAATGAATCACACTTACTTTCTAACAATA
AGGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8HN67

References