47404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 826695..827228 Replicon chromosome
Accession NZ_CP008747
Organism Staphylococcus hyicus strain ATCC 11249

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0A8HPH3
Locus tag SHYC_RS03765 Protein ID WP_039644659.1
Coordinates 826995..827228 (+) Length 78 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0A8HRR0
Locus tag SHYC_RS03760 Protein ID WP_039644657.1
Coordinates 826695..826982 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SHYC_RS03735 821988..822785 + 798 WP_039644648.1 hydroxyethylthiazole kinase -
SHYC_RS03740 822782..823420 + 639 WP_039644650.1 thiamine phosphate synthase -
SHYC_RS03745 823509..824375 + 867 WP_039644652.1 membrane protein insertase YidC -
SHYC_RS03750 824423..825055 - 633 WP_039644653.1 HD domain-containing protein -
SHYC_RS03755 825067..826557 - 1491 WP_039644655.1 cardiolipin synthase -
SHYC_RS03760 826695..826982 + 288 WP_039644657.1 copper-sensing transcriptional repressor CsoR Antitoxin
SHYC_RS03765 826995..827228 + 234 WP_039644659.1 hypothetical protein Toxin
SHYC_RS03770 827221..827424 + 204 WP_039644660.1 cation transporter -
SHYC_RS03775 827553..829733 + 2181 WP_039644662.1 heavy metal translocating P-type ATPase -
SHYC_RS12335 829818..829958 + 141 WP_086375151.1 hypothetical protein -
SHYC_RS03780 830116..831315 - 1200 WP_039644664.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8851.10 Da        Isoelectric Point: 4.7769

>T47404 WP_039644659.1 NZ_CP008747:826995-827228 [Staphylococcus hyicus]
MQIDRVFVEGLDEEQQRTDLTQRLNHMIGVKGVSIDGHLQCVTLKYETPMNLNTLEKEIYDAGFKVLRTVKGEITNE

Download         Length: 234 bp

>T47404 NZ_CP008747:826995-827228 [Staphylococcus hyicus]
ATGCAAATTGATCGTGTGTTTGTAGAGGGATTAGATGAGGAACAACAACGAACAGATTTAACACAACGTTTGAATCATAT
GATAGGGGTTAAAGGAGTAAGTATAGATGGTCACTTACAATGTGTAACACTTAAATATGAAACGCCAATGAATTTAAATA
CGTTAGAAAAAGAAATTTACGATGCTGGTTTTAAAGTATTACGAACAGTAAAAGGAGAGATTACGAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10999.56 Da        Isoelectric Point: 6.3268

>AT47404 WP_039644657.1 NZ_CP008747:826695-826982 [Staphylococcus hyicus]
MNDHAHHSEEIKKNLTSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDYHMKGCITKKIEDGHETE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT47404 NZ_CP008747:826695-826982 [Staphylococcus hyicus]
ATGAATGACCATGCGCATCATTCTGAAGAGATTAAAAAGAACTTAACGTCACGTTTGAATAGAATCGAGGGACAAGTTCG
TGCGATAAATCGCATGATTGATGAAGATGTTTATTGTGACGATGTATTGACACAAATTAGAGCAACACGTTCTGCATTAA
ACAGTGTTGCTACAAAGCTACTCGATTATCACATGAAAGGTTGTATTACAAAGAAAATTGAGGATGGACATGAAACTGAA
GCAATGGAAGAATTGTTGGTCACATTTCAAAAGTTAATGAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HPH3

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8HRR0

References