Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 3717922..3718596 | Replicon | chromosome |
Accession | NZ_CP008744 | ||
Organism | Mycobacterium tuberculosis variant bovis BCG strain 3281 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WF52 |
Locus tag | GS11_RS17495 | Protein ID | WP_003417282.1 |
Coordinates | 3717922..3718350 (-) | Length | 143 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TI59 |
Locus tag | GS11_RS17500 | Protein ID | WP_003417286.1 |
Coordinates | 3718354..3718596 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GS11_RS17470 | 3713744..3714145 | - | 402 | WP_003417264.1 | cytidine deaminase | - |
GS11_RS17475 | 3714286..3714720 | + | 435 | WP_003900017.1 | succinate dehydrogenase, cytochrome b556 subunit | - |
GS11_RS17480 | 3714717..3715151 | + | 435 | WP_003417269.1 | succinate dehydrogenase hydrophobic membrane anchor subunit | - |
GS11_RS17485 | 3715280..3717052 | + | 1773 | WP_003417273.1 | succinate dehydrogenase flavoprotein subunit | - |
GS11_RS17490 | 3717052..3717843 | + | 792 | WP_010950870.1 | succinate dehydrogenase iron-sulfur subunit | - |
GS11_RS17495 | 3717922..3718350 | - | 429 | WP_003417282.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
GS11_RS17500 | 3718354..3718596 | - | 243 | WP_003417286.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
GS11_RS17505 | 3718718..3719332 | - | 615 | WP_003417288.1 | class I SAM-dependent methyltransferase | - |
GS11_RS17510 | 3719329..3719994 | - | 666 | WP_003417290.1 | molybdopterin converting factor subunit 1 | - |
GS11_RS17515 | 3719995..3720528 | - | 534 | WP_003417293.1 | cyclic pyranopterin monophosphate synthase MoaC | - |
GS11_RS17520 | 3720525..3720899 | - | 375 | WP_003417295.1 | 4a-hydroxytetrahydrobiopterin dehydratase | - |
GS11_RS17525 | 3720996..3722060 | - | 1065 | WP_003913037.1 | GTP 3',8-cyclase MoaA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15834.16 Da Isoelectric Point: 8.5471
>T47399 WP_003417282.1 NZ_CP008744:c3718350-3717922 [Mycobacterium tuberculosis variant bovis BCG]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL
Download Length: 429 bp
>T47399 NZ_CP008744:c3718350-3717922 [Mycobacterium tuberculosis variant bovis BCG]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8849.86 Da Isoelectric Point: 5.1007
>AT47399 WP_003417286.1 NZ_CP008744:c3718596-3718354 [Mycobacterium tuberculosis variant bovis BCG]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV
Download Length: 243 bp
>AT47399 NZ_CP008744:c3718596-3718354 [Mycobacterium tuberculosis variant bovis BCG]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FBL0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TI59 |