Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN_Sll0205-like-Phd |
Location | 3070089..3070693 | Replicon | chromosome |
Accession | NZ_CP008744 | ||
Organism | Mycobacterium tuberculosis variant bovis BCG strain 3281 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P71623 |
Locus tag | GS11_RS14550 | Protein ID | WP_003414492.1 |
Coordinates | 3070089..3070481 (-) | Length | 131 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A829CBY8 |
Locus tag | GS11_RS14555 | Protein ID | WP_003414495.1 |
Coordinates | 3070478..3070693 (-) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GS11_RS14520 | 3065239..3066027 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
GS11_RS14525 | 3066361..3066906 | - | 546 | WP_003904931.1 | DUF1802 family protein | - |
GS11_RS14530 | 3067178..3068062 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
GS11_RS14535 | 3068065..3068952 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | - |
GS11_RS14540 | 3069257..3069802 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
GS11_RS14545 | 3069799..3070068 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
GS11_RS14550 | 3070089..3070481 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
GS11_RS14555 | 3070478..3070693 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
GS11_RS14560 | 3070740..3071489 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
GS11_RS14565 | 3071568..3072650 | - | 1083 | WP_011799293.1 | ABC transporter ATP-binding protein | - |
GS11_RS21470 | 3072643..3073953 | - | 1311 | Protein_2839 | ABC transporter substrate-binding protein | - |
GS11_RS14580 | 3073956..3074783 | - | 828 | WP_003414504.1 | carbohydrate ABC transporter permease | - |
GS11_RS14585 | 3074780..3075691 | - | 912 | WP_003414505.1 | sugar ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14610.74 Da Isoelectric Point: 6.7594
>T47394 WP_003414492.1 NZ_CP008744:c3070481-3070089 [Mycobacterium tuberculosis variant bovis BCG]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
Download Length: 393 bp
>T47394 NZ_CP008744:c3070481-3070089 [Mycobacterium tuberculosis variant bovis BCG]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG
Antitoxin
Download Length: 72 a.a. Molecular weight: 7511.55 Da Isoelectric Point: 4.9732
>AT47394 WP_003414495.1 NZ_CP008744:c3070693-3070478 [Mycobacterium tuberculosis variant bovis BCG]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS
Download Length: 216 bp
>AT47394 NZ_CP008744:c3070693-3070478 [Mycobacterium tuberculosis variant bovis BCG]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BWM8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CBY8 |