Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3043096..3043666 | Replicon | chromosome |
Accession | NZ_CP008744 | ||
Organism | Mycobacterium tuberculosis variant bovis BCG strain 3281 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | GS11_RS14400 | Protein ID | WP_003414166.1 |
Coordinates | 3043096..3043452 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | GS11_RS14405 | Protein ID | WP_003901465.1 |
Coordinates | 3043436..3043666 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GS11_RS14380 | 3038548..3040236 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
GS11_RS14385 | 3040240..3040566 | - | 327 | WP_003414157.1 | hypothetical protein | - |
GS11_RS14390 | 3040739..3041326 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
GS11_RS14395 | 3041345..3042994 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
GS11_RS14400 | 3043096..3043452 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
GS11_RS14405 | 3043436..3043666 | - | 231 | WP_003901465.1 | antitoxin MazE | Antitoxin |
GS11_RS14410 | 3043709..3044752 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
GS11_RS22085 | 3044943..3045218 | + | 276 | WP_003911993.1 | DUF1778 domain-containing protein | - |
GS11_RS22090 | 3045394..3045648 | - | 255 | WP_003917684.1 | hypothetical protein | - |
GS11_RS14425 | 3045796..3046200 | + | 405 | WP_003414181.1 | hypothetical protein | - |
GS11_RS14430 | 3046197..3046388 | + | 192 | WP_003414184.1 | hypothetical protein | - |
GS11_RS14435 | 3046452..3047741 | + | 1290 | Protein_2813 | transposase family protein | - |
GS11_RS14440 | 3047975..3048232 | + | 258 | WP_003899489.1 | hypothetical protein | - |
GS11_RS14445 | 3048337..3048648 | + | 312 | WP_010950777.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T47392 WP_003414166.1 NZ_CP008744:c3043452-3043096 [Mycobacterium tuberculosis variant bovis BCG]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T47392 NZ_CP008744:c3043452-3043096 [Mycobacterium tuberculosis variant bovis BCG]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT47392 WP_003901465.1 NZ_CP008744:c3043666-3043436 [Mycobacterium tuberculosis variant bovis BCG]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT47392 NZ_CP008744:c3043666-3043436 [Mycobacterium tuberculosis variant bovis BCG]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|