Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2873996..2874710 Replicon chromosome
Accession NZ_CP008744
Organism Mycobacterium tuberculosis variant bovis BCG strain 3281

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag GS11_RS13445 Protein ID WP_003413460.1
Coordinates 2874270..2874710 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag GS11_RS13440 Protein ID WP_003413456.1
Coordinates 2873996..2874283 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS11_RS13405 2869428..2869673 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GS11_RS13410 2869670..2870074 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
GS11_RS13415 2870291..2870911 + 621 WP_003413441.1 DUF4178 domain-containing protein -
GS11_RS13420 2870922..2871416 + 495 WP_003413444.1 DUF2617 family protein -
GS11_RS13425 2871413..2871844 + 432 WP_003413445.1 DUF4247 domain-containing protein -
GS11_RS13430 2871869..2872317 + 449 Protein_2612 DUF350 domain-containing protein -
GS11_RS13435 2872314..2873885 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
GS11_RS13440 2873996..2874283 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
GS11_RS13445 2874270..2874710 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
GS11_RS13450 2874731..2875486 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
GS11_RS13455 2875619..2876215 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
GS11_RS13460 2876223..2877068 - 846 WP_010950749.1 acyl-CoA thioesterase II -
GS11_RS13465 2877097..2877996 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
GS11_RS13470 2878124..2878798 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T47389 WP_003413460.1 NZ_CP008744:2874270-2874710 [Mycobacterium tuberculosis variant bovis BCG]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T47389 NZ_CP008744:2874270-2874710 [Mycobacterium tuberculosis variant bovis BCG]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT47389 WP_003413456.1 NZ_CP008744:2873996-2874283 [Mycobacterium tuberculosis variant bovis BCG]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT47389 NZ_CP008744:2873996-2874283 [Mycobacterium tuberculosis variant bovis BCG]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References