Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2798200..2798840 Replicon chromosome
Accession NZ_CP008744
Organism Mycobacterium tuberculosis variant bovis BCG strain 3281

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag GS11_RS13075 Protein ID WP_003412970.1
Coordinates 2798200..2798619 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag GS11_RS13080 Protein ID WP_003412975.1
Coordinates 2798616..2798840 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS11_RS13050 2793785..2794507 - 723 WP_003412957.1 DUF1906 domain-containing protein -
GS11_RS13055 2795024..2795251 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
GS11_RS13060 2795248..2795649 + 402 WP_003412963.1 PIN domain-containing protein -
GS11_RS13065 2795684..2796604 - 921 WP_011799273.1 restriction endonuclease -
GS11_RS22355 2796945..2797190 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GS11_RS13070 2797249..2798199 + 951 WP_003911916.1 Lsr2 family protein -
GS11_RS13075 2798200..2798619 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
GS11_RS13080 2798616..2798840 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
GS11_RS13085 2798871..2801714 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
GS11_RS13090 2801786..2802187 - 402 WP_003412981.1 hypothetical protein -
GS11_RS13095 2802187..2802657 - 471 WP_003412985.1 transcription antitermination factor NusB -
GS11_RS13100 2802660..2803223 - 564 WP_003412989.1 elongation factor P -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-128)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T47385 WP_003412970.1 NZ_CP008744:c2798619-2798200 [Mycobacterium tuberculosis variant bovis BCG]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T47385 NZ_CP008744:c2798619-2798200 [Mycobacterium tuberculosis variant bovis BCG]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT47385 WP_003412975.1 NZ_CP008744:c2798840-2798616 [Mycobacterium tuberculosis variant bovis BCG]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT47385 NZ_CP008744:c2798840-2798616 [Mycobacterium tuberculosis variant bovis BCG]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ08


Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References