Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2185984..2186528 | Replicon | chromosome |
| Accession | NZ_CP008744 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain 3281 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | GS11_RS10160 | Protein ID | WP_003409896.1 |
| Coordinates | 2185984..2186280 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | GS11_RS10165 | Protein ID | WP_003409899.1 |
| Coordinates | 2186277..2186528 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GS11_RS10105 | 2181017..2181367 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| GS11_RS10110 | 2181378..2182280 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| GS11_RS10115 | 2182301..2182492 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| GS11_RS10120 | 2182493..2182789 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| GS11_RS10125 | 2183029..2183244 | + | 216 | WP_003409878.1 | antitoxin | - |
| GS11_RS10130 | 2183241..2183552 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| GS11_RS22325 | 2183526..2184047 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| GS11_RS10140 | 2184022..2184399 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| GS11_RS10145 | 2184441..2184890 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| GS11_RS10150 | 2184887..2185432 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| GS11_RS10155 | 2185321..2185935 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| GS11_RS10160 | 2185984..2186280 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GS11_RS10165 | 2186277..2186528 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| GS11_RS10170 | 2186515..2187009 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| GS11_RS10175 | 2187169..2187576 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| GS11_RS10180 | 2187580..2187852 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GS11_RS10185 | 2187885..2189105 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| GS11_RS10195 | 2190004..2190309 | + | 306 | Protein_1989 | ABC transporter permease | - |
| GS11_RS10200 | 2190493..2191017 | + | 525 | WP_011799234.1 | methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T47376 WP_003409896.1 NZ_CP008744:c2186280-2185984 [Mycobacterium tuberculosis variant bovis BCG]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T47376 NZ_CP008744:c2186280-2185984 [Mycobacterium tuberculosis variant bovis BCG]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT47376 WP_003409899.1 NZ_CP008744:c2186528-2186277 [Mycobacterium tuberculosis variant bovis BCG]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT47376 NZ_CP008744:c2186528-2186277 [Mycobacterium tuberculosis variant bovis BCG]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |