47370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1683241..1683857 Replicon chromosome
Accession NZ_CP008744
Organism Mycobacterium tuberculosis variant bovis BCG strain 3281

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag GS11_RS07920 Protein ID WP_003407593.1
Coordinates 1683540..1683857 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U4BU54
Locus tag GS11_RS07915 Protein ID WP_011799188.1
Coordinates 1683241..1683543 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS11_RS07905 1679127..1680974 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
GS11_RS07910 1680975..1683227 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
GS11_RS07915 1683241..1683543 + 303 WP_011799188.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
GS11_RS07920 1683540..1683857 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
GS11_RS07925 1683854..1684858 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
GS11_RS07930 1684911..1686200 + 1290 WP_003407599.1 serine hydrolase -
GS11_RS07935 1686273..1687046 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
GS11_RS07940 1687104..1687295 - 192 WP_003407609.1 dodecin family protein -
GS11_RS22315 1687326..1687550 - 225 WP_160522526.1 NUDIX domain-containing protein -
GS11_RS07950 1687820..1688848 + 1029 WP_011799189.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T47370 WP_003407593.1 NZ_CP008744:1683540-1683857 [Mycobacterium tuberculosis variant bovis BCG]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T47370 NZ_CP008744:1683540-1683857 [Mycobacterium tuberculosis variant bovis BCG]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11199.50 Da        Isoelectric Point: 9.5564

>AT47370 WP_011799188.1 NZ_CP008744:1683241-1683543 [Mycobacterium tuberculosis variant bovis BCG]
VPFLVALSGIILGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT47370 NZ_CP008744:1683241-1683543 [Mycobacterium tuberculosis variant bovis BCG]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTTGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BU54

References