Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1390307..1390866 Replicon chromosome
Accession NZ_CP008744
Organism Mycobacterium tuberculosis variant bovis BCG strain 3281

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag GS11_RS06605 Protein ID WP_003898789.1
Coordinates 1390307..1390600 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag GS11_RS06610 Protein ID WP_003406322.1
Coordinates 1390597..1390866 (-) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS11_RS06580 1385900..1386160 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
GS11_RS06585 1386157..1386588 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
GS11_RS06590 1386611..1388299 - 1689 WP_003910308.1 PE family protein -
GS11_RS06595 1388479..1389339 + 861 WP_003406306.1 hypothetical protein -
GS11_RS06600 1389420..1390250 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
GS11_RS06605 1390307..1390600 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
GS11_RS06610 1390597..1390866 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GS11_RS06615 1390979..1394674 - 3696 WP_010950509.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
GS11_RS06620 1394816..1395604 - 789 WP_010950510.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T47367 WP_003898789.1 NZ_CP008744:c1390600-1390307 [Mycobacterium tuberculosis variant bovis BCG]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T47367 NZ_CP008744:c1390600-1390307 [Mycobacterium tuberculosis variant bovis BCG]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT47367 WP_003406322.1 NZ_CP008744:c1390866-1390597 [Mycobacterium tuberculosis variant bovis BCG]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT47367 NZ_CP008744:c1390866-1390597 [Mycobacterium tuberculosis variant bovis BCG]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0THS1


Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References