Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 754734..755367 Replicon chromosome
Accession NZ_CP008744
Organism Mycobacterium tuberculosis variant bovis BCG strain 3281

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag GS11_RS03455 Protein ID WP_003403365.1
Coordinates 754734..755117 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag GS11_RS03460 Protein ID WP_003403368.1
Coordinates 755212..755367 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS11_RS03430 750026..750562 + 537 WP_003403341.1 50S ribosomal protein L10 -
GS11_RS03435 750599..750991 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
GS11_RS03440 750984..751679 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
GS11_RS03445 751750..753255 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
GS11_RS03450 753336..754346 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
GS11_RS03455 754734..755117 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
GS11_RS03460 755212..755367 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GS11_RS03465 755443..756159 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
GS11_RS03470 756435..756743 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
GS11_RS03475 756730..756975 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
GS11_RS03480 757085..757522 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
GS11_RS03485 757519..757773 - 255 WP_003911263.1 antitoxin VapB7 -
GS11_RS03490 757887..760250 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T47356 WP_003403365.1 NZ_CP008744:c755117-754734 [Mycobacterium tuberculosis variant bovis BCG]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T47356 NZ_CP008744:c755117-754734 [Mycobacterium tuberculosis variant bovis BCG]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT47356 WP_003403368.1 NZ_CP008744:c755367-755212 [Mycobacterium tuberculosis variant bovis BCG]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT47356 NZ_CP008744:c755367-755212 [Mycobacterium tuberculosis variant bovis BCG]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References