Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1380284..1381761 Replicon chromosome
Accession NZ_CP008743
Organism Candidatus Nucleicultrix amoebiphila FS5

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag GQ61_RS06845 Protein ID WP_085784614.1
Coordinates 1380517..1381761 (+) Length 415 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag GQ61_RS06840 Protein ID WP_085784613.1
Coordinates 1380284..1380493 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ61_RS06825 1375372..1378527 + 3156 WP_085784610.1 efflux RND transporter permease subunit -
GQ61_RS06830 1378719..1379015 + 297 WP_085784611.1 metal-sensitive transcriptional regulator -
GQ61_RS06835 1379029..1379577 + 549 WP_085784612.1 hypothetical protein -
GQ61_RS06840 1380284..1380493 + 210 WP_085784613.1 helix-turn-helix transcriptional regulator Antitoxin
GQ61_RS06845 1380517..1381761 + 1245 WP_085784614.1 type II toxin-antitoxin system HipA family toxin Toxin
GQ61_RS06850 1381972..1383048 + 1077 WP_085784615.1 Fic family protein -
GQ61_RS06855 1383608..1384378 + 771 WP_085784616.1 type IV toxin-antitoxin system AbiEi family antitoxin -
GQ61_RS06860 1384356..1385279 + 924 WP_085784617.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
GQ61_RS06870 1385513..1386631 - 1119 WP_085784618.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 415 a.a.        Molecular weight: 46829.24 Da        Isoelectric Point: 6.2522

>T47342 WP_085784614.1 NZ_CP008743:1380517-1381761 [Candidatus Nucleicultrix amoebiphila FS5]
MAKSLDVYLEDKFVGNLIQDNHGQMLFSYAEIWLENPNAIPLSQSLPLRKDRFSPKECRGFFAGILPEQSMRKTVATILG
ISSENDFSMLERIGGECAGAVVFIPSGEKLQTSFNYQEINEQELAKILRELPHRPLMAGEQDIRLSLAGVQDKVAVRILN
DKISIPHGIAPSTHILKPAIERFEGTVFNEALCMGLADAIGLSTAKIEIGRAEDIDYLIVERYDRMMLRINPELIQLIRL
HQEDFCQALGIVPEKKYQSEEGPSLKQCFEILRKVSSAPVIDLQRLLDAVIFNFLVGNHDAHGKNFSLLYNLTTSNTRLA
PLYDILSTDYYPTLSKKMAMKIGDEYLSEKIQPKHFEELAEEAGLSKPFVKRRVPDLAQMILSKLPEVVMDHPVSTAVAK
LIQNRCERRIREFK

Download         Length: 1245 bp

>T47342 NZ_CP008743:1380517-1381761 [Candidatus Nucleicultrix amoebiphila FS5]
ATGGCAAAATCACTGGATGTCTATTTAGAAGATAAGTTCGTAGGAAATCTCATCCAAGATAATCACGGCCAAATGCTCTT
TTCTTATGCGGAAATATGGCTTGAGAACCCCAACGCCATTCCTTTATCTCAGTCTTTACCTTTGCGCAAAGATCGTTTTT
CACCTAAAGAATGTCGCGGTTTTTTTGCAGGCATCTTACCAGAGCAAAGCATGAGAAAAACGGTTGCTACTATTTTAGGC
ATTAGTTCTGAAAATGATTTTTCCATGTTAGAGCGCATAGGAGGAGAGTGCGCTGGAGCTGTTGTATTCATACCCTCCGG
CGAGAAACTACAAACGAGTTTTAATTATCAGGAAATAAATGAGCAAGAATTAGCAAAAATCCTAAGAGAATTACCTCATC
GACCACTTATGGCTGGTGAGCAAGACATTCGACTCTCCCTGGCGGGCGTACAAGACAAAGTCGCTGTACGCATTTTGAAT
GACAAAATTTCTATACCTCATGGCATAGCACCCAGTACACATATACTAAAGCCAGCGATTGAGCGCTTTGAGGGGACGGT
TTTTAATGAAGCTCTTTGCATGGGGCTCGCTGATGCAATAGGTCTTTCAACTGCAAAAATAGAAATTGGTCGTGCAGAAG
ACATAGATTATCTTATTGTAGAACGTTATGACAGAATGATGCTTCGTATAAATCCTGAATTAATCCAATTAATACGATTG
CATCAAGAGGATTTTTGCCAAGCTTTGGGTATTGTTCCAGAAAAAAAATACCAAAGTGAGGAAGGGCCTTCTTTAAAGCA
ATGCTTTGAAATATTGCGAAAGGTGTCTAGCGCGCCAGTAATTGATCTTCAACGTTTACTAGATGCCGTCATTTTTAATT
TTCTTGTCGGGAATCATGACGCCCATGGGAAAAATTTTTCTTTGCTTTATAATTTAACGACGTCAAATACAAGACTAGCA
CCTCTATATGATATATTGAGTACCGATTATTATCCGACCCTTTCAAAAAAAATGGCCATGAAAATTGGTGATGAATATCT
TTCTGAGAAAATCCAACCAAAACATTTTGAGGAATTAGCTGAAGAAGCGGGCCTCTCTAAACCGTTCGTAAAACGGCGTG
TTCCTGACCTCGCTCAAATGATTCTGTCTAAGCTTCCAGAAGTTGTAATGGATCATCCGGTTTCGACGGCTGTCGCAAAA
CTCATTCAAAATCGTTGTGAACGAAGAATACGTGAATTTAAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7726.22 Da        Isoelectric Point: 10.3201

>AT47342 WP_085784613.1 NZ_CP008743:1380284-1380493 [Candidatus Nucleicultrix amoebiphila FS5]
MKYTTEQIGKLVRETRKRLGVTQKELALTSGTGLRFIIELEKGKPTCQLSKVLTVLYTLGIDMTLFPPA

Download         Length: 210 bp

>AT47342 NZ_CP008743:1380284-1380493 [Candidatus Nucleicultrix amoebiphila FS5]
ATGAAATATACAACTGAGCAAATTGGAAAACTCGTTAGAGAAACACGTAAACGGCTTGGAGTGACACAAAAGGAATTGGC
ACTTACTTCTGGCACAGGGCTACGCTTTATTATTGAGTTGGAAAAAGGTAAACCGACTTGCCAATTGAGTAAGGTATTAA
CCGTTTTATACACTCTTGGAATAGATATGACATTATTTCCCCCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References