Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 1077561..1078132 Replicon chromosome
Accession NZ_CP008743
Organism Candidatus Nucleicultrix amoebiphila FS5

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GQ61_RS05190 Protein ID WP_085784302.1
Coordinates 1077561..1077887 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GQ61_RS05195 Protein ID WP_085784303.1
Coordinates 1077881..1078132 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ61_RS05170 1073676..1075472 + 1797 WP_085784298.1 aminopeptidase P family protein -
GQ61_RS05175 1075469..1076653 - 1185 WP_085784299.1 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase -
GQ61_RS05180 1076765..1077067 + 303 WP_085784300.1 type II toxin-antitoxin system HigB family toxin -
GQ61_RS05185 1077057..1077461 + 405 WP_085784301.1 hypothetical protein -
GQ61_RS05190 1077561..1077887 - 327 WP_085784302.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GQ61_RS05195 1077881..1078132 - 252 WP_085784303.1 hypothetical protein Antitoxin
GQ61_RS05200 1078383..1078694 + 312 WP_085784304.1 HigA family addiction module antidote protein -
GQ61_RS05205 1078691..1080337 + 1647 WP_085784305.1 STAS domain-containing protein -
GQ61_RS05210 1080360..1080887 - 528 WP_085785070.1 demethoxyubiquinone hydroxylase family protein -
GQ61_RS05215 1080896..1081375 - 480 WP_198157278.1 disulfide bond formation protein B -
GQ61_RS05220 1081396..1081977 - 582 WP_085784307.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1026016..1083536 57520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12525.98 Da        Isoelectric Point: 10.4308

>T47340 WP_085784302.1 NZ_CP008743:c1077887-1077561 [Candidatus Nucleicultrix amoebiphila FS5]
MVDIKRFDICLINLDPTLGSEIKKMRPCVVISPDEMNRNINTIIVAPMTTKSRKYPTRIKITFEGKEGQIVLDQIRTIDK
IRIVKKLGKIHQKTAHEVLRSLIEMFSY

Download         Length: 327 bp

>T47340 NZ_CP008743:c1077887-1077561 [Candidatus Nucleicultrix amoebiphila FS5]
ATGGTAGATATTAAGCGTTTTGATATCTGTCTTATTAACTTAGATCCGACTCTTGGATCAGAAATTAAGAAAATGAGGCC
GTGTGTTGTCATTTCTCCCGATGAGATGAACAGGAACATCAACACTATTATTGTAGCTCCTATGACTACTAAGTCACGTA
AGTACCCTACAAGAATTAAGATTACCTTCGAAGGCAAAGAAGGTCAGATCGTCTTAGATCAAATTAGGACAATTGATAAA
ATACGTATTGTAAAGAAATTAGGAAAAATTCATCAAAAGACCGCTCATGAAGTTTTGAGATCTCTTATAGAAATGTTTTC
TTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9939.32 Da        Isoelectric Point: 6.4632

>AT47340 WP_085784303.1 NZ_CP008743:c1078132-1077881 [Candidatus Nucleicultrix amoebiphila FS5]
MRINIIQIGNSKGIRLPKYVFKSCHFQEAVDLEIEDDKVILRNIERKPRHNWDSSFKKMALAGDDKLLDEYSTTNWDVDE
WKW

Download         Length: 252 bp

>AT47340 NZ_CP008743:c1078132-1077881 [Candidatus Nucleicultrix amoebiphila FS5]
ATGCGTATCAATATCATTCAAATTGGCAATTCAAAAGGAATTCGTCTTCCTAAGTACGTTTTTAAGAGTTGTCATTTCCA
AGAGGCTGTAGATCTTGAAATCGAAGATGATAAGGTTATCCTTCGCAATATCGAGCGTAAACCTAGGCATAATTGGGATT
CTTCATTTAAAAAGATGGCATTAGCAGGTGATGATAAGCTGCTCGACGAATATTCTACAACGAACTGGGACGTAGATGAG
TGGAAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References