Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 429133..429631 Replicon chromosome
Accession NZ_CP008743
Organism Candidatus Nucleicultrix amoebiphila FS5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GQ61_RS01950 Protein ID WP_085783687.1
Coordinates 429133..429408 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag GQ61_RS01955 Protein ID WP_085783688.1
Coordinates 429401..429631 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ61_RS01935 424962..425726 - 765 WP_085783684.1 hypothetical protein -
GQ61_RS01940 425726..426499 - 774 WP_085783685.1 toxin-antitoxin system YwqK family antitoxin -
GQ61_RS01945 426510..429011 - 2502 WP_085783686.1 type VI secretion system tip protein VgrG -
GQ61_RS01950 429133..429408 - 276 WP_085783687.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQ61_RS01955 429401..429631 - 231 WP_085783688.1 ribbon-helix-helix protein, CopG family Antitoxin
GQ61_RS01960 429897..430577 - 681 WP_085783689.1 DNA repair protein RadC -
GQ61_RS01965 430650..430955 + 306 WP_085783690.1 DUF167 domain-containing protein -
GQ61_RS01970 430945..431343 - 399 WP_085783691.1 hypothetical protein -
GQ61_RS01975 431436..431927 - 492 WP_085783692.1 transcription antitermination factor NusB -
GQ61_RS01985 432214..433356 - 1143 WP_085783693.1 patatin-like phospholipase family protein -
GQ61_RS01990 433462..433914 - 453 WP_085783694.1 HIT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-90)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10779.77 Da        Isoelectric Point: 10.8043

>T47339 WP_085783687.1 NZ_CP008743:c429408-429133 [Candidatus Nucleicultrix amoebiphila FS5]
MNKPFWKVVFTTKSEKTFFKLEVKVQKQIQGYLRTKIATSMNPRRLGKPLSGKLSGFWRYRVGDYRLICSIQDDELIVLM
VTIGHRKDIYH

Download         Length: 276 bp

>T47339 NZ_CP008743:c429408-429133 [Candidatus Nucleicultrix amoebiphila FS5]
TTGAATAAACCTTTTTGGAAAGTGGTCTTTACAACCAAATCCGAAAAAACTTTTTTTAAGCTAGAAGTTAAAGTTCAAAA
ACAGATTCAAGGGTATTTGAGAACAAAAATCGCAACGTCTATGAATCCGAGAAGATTAGGTAAACCTTTGAGTGGTAAGC
TTTCTGGTTTCTGGCGCTATCGAGTGGGCGATTATCGTCTTATTTGCTCTATTCAAGATGATGAGTTGATTGTGCTTATG
GTTACAATAGGACATCGCAAAGACATTTATCACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9017.33 Da        Isoelectric Point: 5.9124

>AT47339 WP_085783688.1 NZ_CP008743:c429631-429401 [Candidatus Nucleicultrix amoebiphila FS5]
MTTAVRLPEDLEHRLENLVQKTNRSKSYYIRKALEEFLEDREDYLLAASRWEEFVKSGKKGISLEEVEKKMGLKIE

Download         Length: 231 bp

>AT47339 NZ_CP008743:c429631-429401 [Candidatus Nucleicultrix amoebiphila FS5]
ATGACCACTGCTGTAAGATTACCTGAAGATTTAGAACACAGGCTTGAGAACCTCGTCCAGAAAACGAATCGATCAAAAAG
TTACTATATTCGAAAGGCTCTAGAAGAATTTCTTGAAGATCGTGAAGACTATCTCTTAGCAGCTTCCCGTTGGGAAGAGT
TTGTCAAGAGCGGTAAAAAAGGAATTTCTTTAGAAGAAGTTGAAAAGAAAATGGGGTTAAAAATTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References