Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1440436..1441025 Replicon chromosome
Accession NZ_CP008740
Organism Haemophilus influenzae 2019

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag C645_RS07385 Protein ID WP_005653200.1
Coordinates 1440436..1440684 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag C645_RS07390 Protein ID WP_005653201.1
Coordinates 1440681..1441025 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C645_RS07360 1435626..1436258 + 633 WP_046067782.1 energy-coupling factor transporter transmembrane protein EcfT -
C645_RS07365 1436259..1436876 + 618 WP_005667285.1 energy-coupling factor ABC transporter ATP-binding protein -
C645_RS07370 1437035..1438225 - 1191 WP_046067783.1 aspartate/tyrosine/aromatic aminotransferase -
C645_RS07375 1438365..1439453 - 1089 WP_046067784.1 5-(carboxyamino)imidazole ribonucleotide synthase -
C645_RS07380 1439523..1440017 - 495 WP_046067785.1 5-(carboxyamino)imidazole ribonucleotide mutase -
C645_RS07385 1440436..1440684 + 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
C645_RS07390 1440681..1441025 + 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C645_RS07395 1441069..1443678 + 2610 WP_046067786.1 aminopeptidase N -
C645_RS07400 1443750..1444364 - 615 WP_005657019.1 riboflavin synthase -
C645_RS07405 1444408..1445802 + 1395 WP_046067787.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T47330 WP_005653200.1 NZ_CP008740:1440436-1440684 [Haemophilus influenzae 2019]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T47330 NZ_CP008740:1440436-1440684 [Haemophilus influenzae 2019]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT47330 WP_005653201.1 NZ_CP008740:1440681-1441025 [Haemophilus influenzae 2019]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT47330 NZ_CP008740:1440681-1441025 [Haemophilus influenzae 2019]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References