Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1092453..1092987 Replicon chromosome
Accession NZ_CP008740
Organism Haemophilus influenzae 2019

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3PGA1
Locus tag C645_RS05605 Protein ID WP_005655869.1
Coordinates 1092453..1092743 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H3PEU6
Locus tag C645_RS05610 Protein ID WP_005655871.1
Coordinates 1092733..1092987 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C645_RS05590 1090006..1090509 + 504 WP_005651506.1 hypothetical protein -
C645_RS05595 1090509..1091543 + 1035 WP_005655864.1 DNA polymerase III subunit delta -
C645_RS10305 1092012..1092149 - 138 WP_168769336.1 hypothetical protein -
C645_RS10310 1092172..1092372 - 201 WP_079997614.1 hypothetical protein -
C645_RS05605 1092453..1092743 - 291 WP_005655869.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C645_RS05610 1092733..1092987 - 255 WP_005655871.1 stability protein StbD Antitoxin
C645_RS05615 1093078..1093284 - 207 WP_005655873.1 hypothetical protein -
C645_RS10315 1093293..1093517 - 225 Protein_1067 hypothetical protein -
C645_RS05620 1093517..1093825 - 309 WP_005655879.1 P2 family phage major capsid protein -
C645_RS05625 1093855..1094526 - 672 WP_005655881.1 integrase arm-type DNA-binding domain-containing protein -
C645_RS05635 1094887..1096953 - 2067 WP_005688396.1 glycine--tRNA ligase subunit beta -
C645_RS05640 1097291..1097656 - 366 WP_005659156.1 endonuclease domain-containing protein -
C645_RS05645 1097687..1097947 - 261 WP_005659157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11510.47 Da        Isoelectric Point: 10.6484

>T47329 WP_005655869.1 NZ_CP008740:c1092743-1092453 [Haemophilus influenzae 2019]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLVERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T47329 NZ_CP008740:c1092743-1092453 [Haemophilus influenzae 2019]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGTCGAAAGAATGATAAATCCACGTATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACCATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9415.78 Da        Isoelectric Point: 4.0737

>AT47329 WP_005655871.1 NZ_CP008740:c1092987-1092733 [Haemophilus influenzae 2019]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRIANERLATLEPIEVD
LNDL

Download         Length: 255 bp

>AT47329 NZ_CP008740:c1092987-1092733 [Haemophilus influenzae 2019]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACGCCTGAATTATTTTCTCATA
TGCAAGAGCTAATCGAAGATTTAGAGCTCGGCAGAATAGCAAATGAACGGCTAGCCACCCTAGAACCTATAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PGA1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PEU6

References