Detailed information of TA system TA047326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 793793..794264
• Replicon: chromosome
• Accession: NZ_CP008740
• Organism: Haemophilus influenzae 2019

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: C645_RS04130
• Protein ID: WP_005654546.1
• Coordinates: 794082..794264 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: C645_RS04125
• Protein ID: WP_005650837.1
• Coordinates: 793793..794089 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C645_RS04095	788825..789388	-	564	WP_005690125.1	DNA-3-methyladenine glycosylase I	-
C645_RS04100	789497..789706	-	210	Protein_767	DUF3800 domain-containing protein	-
C645_RS04105	789758..790564	-	807	WP_046067651.1	shikimate dehydrogenase	-
C645_RS04110	790568..791119	-	552	WP_046067652.1	Sua5/YciO/YrdC/YwlC family protein	-
C645_RS04115	791135..791683	-	549	WP_046067653.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
C645_RS04120	791693..793609	-	1917	WP_046067654.1	ABC transporter ATP-binding protein	-
C645_RS04125	793793..794089	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
C645_RS04130	794082..794264	-	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
C645_RS04135	794534..797590	-	3057	WP_154232031.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T47326 WP_005654546.1 NZ_CP008740:c794264-794082 [Haemophilus influenzae 2019]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T47326 NZ_CP008740:c794264-794082 [Haemophilus influenzae 2019]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAATATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT47326 WP_005650837.1 NZ_CP008740:c794089-793793 [Haemophilus influenzae 2019]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT47326 NZ_CP008740:c794089-793793 [Haemophilus influenzae 2019]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9